Lyme Phase III efficacy and regulatory path
Phase III readout showed clinically meaningful efficacy (overall efficacy above 70%); first prespecified statistical criterion not met but the second prespecified analysis met the lower bound (95% CI lower bound >20). Vaccine was well tolerated with no safety concerns; Pfizer is planning submissions to regulatory authorities.
Strong cash position
Total cash and cash equivalents at end-March 2026 were EUR 105.0 million (reported as "more than EUR 100 million"); this excludes proceeds from April 2026 financing.
Comprehensive operating expense reduction program
Launched program targeting a global workforce reduction of ~10%–15% and aiming for a 25%–35% reduction in operating expenses versus 2025 to preserve cash and extend runway.
Chikungunya progress and Brazil pilot campaign
IXCHIQ pilot vaccination campaign in Brazil has vaccinated >30,000 people to date, targeting >100,000; locally produced Butantan-chik achieved licensure in Brazil; study 406 (safety database) is well advanced and nearing enrollment completion.
Shigella program advancement
Tetravalent Shigella candidate is one of the most advanced programs: two studies ongoing (children in Africa and a CHIM immunogenicity/pilot efficacy study) with readouts expected over the summer; partner LimmaTech reported positive Phase I/II results; target global market > EUR 0.5 billion annually.
Strategic R&D focus and potential upside from Lyme
Company planning for potential Lyme success and to scale its R&D pipeline (organic and inorganic expansion), positioning to leverage core vaccine development capabilities and extend beyond vector-borne diseases.