Stable Total Revenues and Product Sales
Total revenues exceeded EUR 170 million in FY2025 with product sales of EUR 157.9 million (down -3.3% YoY; -1.3% at constant currency), reflecting overall stability vs. 2024 despite FX headwinds and strategic reduction of third‑party sales.
Proprietary Product Growth
Proprietary product sales grew ~+9% year‑over‑year excluding currency effects. IXIARO sales rose to EUR 98.4 million (+4.6% YoY; +7.2% at constant currency). IXCHIQ sales increased to EUR 8.4 million from EUR 3.7 million (approx. +127%), including supply of 40,000 doses to La Réunion.
Improved Cash Position and Liquidity Actions
Year‑end cash position nearly EUR 110 million and the company completed a successful debt refinancing (new 5‑year product loan with Pharmakon), enhancing financial flexibility.
Reduced Operating Cash Burn and Cost Discipline
Management reported more than a 20% reduction in operating cash burn driven by disciplined cash management; marketing & distribution and G&A expenses were reduced (M&D down ~-28.6% to EUR 37.4 million; G&A down ~-12.9% to EUR 37.3 million).
One‑time Revenue Recognition Strengthens Other Income
Other revenues rose from EUR 6.3 million to EUR 16.8 million, driven largely by a EUR 10 million revenue recognition related to the Lyme agreement with Pfizer (previously recorded as a refund liability).
Advancing Key Pipeline Programs — Lyme (VLA15) Nearing Readout
Phase III VALOR study (approx. 10,000 participants) for VLA15 (Lyme vaccine, partnered with Pfizer) completed vaccinations and is anticipated to report pivotal data in H1 2026; management described this program as potentially transformational if positive.
Additional R&D Milestones Expected in 2026
Two Phase II programs for the tetravalent Shigella candidate (S4V2) — an infant study and a controlled human infection model — are ongoing with data expected mid‑2026; continued post‑marketing activities and a pilot vaccination campaign for IXCHIQ in Brazil are also underway.
Strategic Refocus on Proprietary Portfolio
Planned termination and reduction of third‑party distribution (third‑party sales reduced from EUR 33.2 million to EUR 19.2 million, ~-42%) reflects a deliberate shift to concentrate on company‑owned vaccines and higher margin opportunities.