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Defence Therapeutics (TSE:DTC)
:DTC

Defence Therapeutics (DTC) AI Stock Analysis

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TSE:DTC

Defence Therapeutics

(DTC)

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Neutral 45 (OpenAI - 5.2)
Rating:45Neutral
Price Target:
C$0.66
▼(-15.00% Downside)
The score is held down primarily by very weak financial performance (no revenue, cash burn, negative equity) and bearish technical signals (below key moving averages with negative MACD). Positive corporate developments around the Accum®/ADC platform and strategic governance/financing actions provide some support but are not enough to outweigh the current financial and trend risks.

Defence Therapeutics (DTC) vs. iShares MSCI Canada ETF (EWC)

Defence Therapeutics Business Overview & Revenue Model

Company DescriptionDefence Therapeutics Inc., a biotechnology company, engages in the research and development of biological/biosimilar therapeutic drugs for cancer and infectious diseases. Its proprietary platform is the ACCUMTM technology, which enables precision delivery of vaccine antigens or ADCs in their intact form to target cells. The company focuses on developing dendritic cell cancer vaccines; protein-based vaccine formulation against COVID and infectious diseases; and antibody drug conjugates (ADC) products targeting various cancers. The company was formerly known as Accum Therapeutics Inc. and changed its name to Defence Therapeutics Inc. in March 2020. Defence Therapeutics Inc. was incorporated in 2017 and is headquartered in Vancouver, Canada.
How the Company Makes MoneyDefence Therapeutics generates revenue through the development and commercialization of its proprietary Accum™ technology, which is licensed to pharmaceutical companies and research institutions. The company earns income from licensing agreements, research and development collaborations, and potentially milestone payments and royalties from partners that utilize its technology in their therapeutic development. Additionally, Defence Therapeutics may receive funding from government grants or subsidies for their contribution to advancing healthcare solutions.

Defence Therapeutics Financial Statement Overview

Summary
Defence Therapeutics is struggling financially with no revenue growth, significant losses, negative equity, and reliance on financing for cash. Immediate strategic changes are necessary to improve financial health and sustainability.
Income Statement
Defence Therapeutics has faced consistent revenue challenges, with total revenue remaining at zero over the reported periods. The company shows significant negative EBIT, EBITDA, and net income, indicating a lack of profitability and efficiency. The absence of revenue growth and persistent losses are major concerns.
Balance Sheet
The company's financial stability is concerning with a negative stockholders' equity, indicating liabilities exceed assets. High leverage is evident with a total debt that significantly surpasses equity, posing a risk to financial health. The equity ratio is negative, further highlighting financial distress.
Cash Flow
Defence Therapeutics experiences negative operating and free cash flows, reflecting inadequate cash generation for operational needs and capital expenditures. The company relies on financing activities for cash inflow, which is unsustainable long-term. There is no visible growth in free cash flow.
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue0.000.000.000.000.000.00
Gross Profit-53.16K-72.34K-90.92K-13.82K0.000.00
EBITDA-3.25M-3.13M-12.68M-6.48M0.000.00
Net Income-3.62M-3.52M-13.19M-6.76M-7.34M-2.86M
Balance Sheet
Total Assets2.77M1.65M477.75K3.53M719.67K5.61M
Cash, Cash Equivalents and Short-Term Investments2.32M1.23M56.55K2.79M506.70K5.45M
Total Debt2.97M1.50M1.75M1.75M0.000.00
Total Liabilities4.18M2.91M4.06M1.97M1.11M122.26K
Stockholders Equity-1.41M-1.26M-3.58M1.57M-387.56K5.49M
Cash Flow
Free Cash Flow-3.41M-3.40M-4.49M-7.72M-6.04M-2.29M
Operating Cash Flow-4.21M-3.40M-4.29M-7.66M-6.04M-2.29M
Investing Cash Flow-17.52K3.60K-203.24K-65.80K0.000.00
Financing Cash Flow6.41M4.57M1.76M10.01M1.10M5.88M

Defence Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.78
Price Trends
50DMA
0.79
Negative
100DMA
0.77
Negative
200DMA
0.79
Negative
Market Momentum
MACD
-0.03
Negative
RSI
46.29
Neutral
STOCH
31.25
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TSE:DTC, the sentiment is Negative. The current price of 0.78 is above the 20-day moving average (MA) of 0.74, below the 50-day MA of 0.79, and below the 200-day MA of 0.79, indicating a bearish trend. The MACD of -0.03 indicates Negative momentum. The RSI at 46.29 is Neutral, neither overbought nor oversold. The STOCH value of 31.25 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for TSE:DTC.

Defence Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
52
Neutral
C$183.31M-29.02-66.34%59.00%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
49
Neutral
C$32.66M-14.87-8.01%-26.81%-161.24%
45
Neutral
C$39.40M-10.1772.92%
43
Neutral
$106.70M-3.53-745.66%
42
Neutral
C$45.35M-11.21-41.70%-35.42%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
TSE:DTC
Defence Therapeutics
0.72
0.12
20.00%
ONCY
Oncolytics Biotech
0.99
0.16
19.25%
TSE:HBP
Helix BioPharma
2.40
1.50
166.67%
TSE:MBX
Microbix Biosystms
0.24
-0.19
-44.05%
TSE:MIR
Medmira
0.07
-0.07
-50.00%
TSE:NRX
NurExone Biologic
0.64
-0.05
-7.25%

Defence Therapeutics Corporate Events

Business Operations and StrategyShareholder Meetings
Defence Therapeutics Announces AGM Results and Strategic Updates
Positive
Dec 10, 2025

Defence Therapeutics announced the successful approval of all matters at its annual general meeting, including the election of directors and the appointment of auditors. The company has granted 800,000 stock options and amended the terms of 967,000 common share purchase warrants, extending their expiry date and adjusting the exercise price. Additionally, Defence has engaged i2i Marketing Group for a two-month online marketing campaign to enhance its market presence.

Business Operations and StrategyExecutive/Board Changes
Defence Therapeutics Forms Scientific Advisory Board to Propel ADC Programs
Positive
Dec 4, 2025

Defence Therapeutics has announced the formation of its inaugural Scientific Advisory Board (SAB) to guide the advancement of its Accum-enhanced Antibody Drug Conjugate (ADC) programs. The SAB, comprising experts in antibody-based therapeutics and biotechnology, will provide strategic guidance as the company progresses its Accum-enabled ADC programs from preclinical development towards clinical applications. This move is expected to strengthen Defence’s scientific foundation and support its long-term development strategy, potentially enhancing its position in the biotechnology industry.

Business Operations and StrategyPrivate Placements and Financing
Defence Therapeutics Completes Convertible Debenture Conversion
Positive
Nov 22, 2025

Defence Therapeutics has announced the conversion of its 8% convertible debentures into 2,607,600 common shares, valued at a total of $1,594,080, upon reaching maturity. This strategic financial move reflects the company’s ongoing efforts to bolster its capital structure, potentially enhancing its market position and operational capabilities in the biotechnology sector.

Business Operations and StrategyProduct-Related Announcements
Defence Therapeutics Advances ADC Drug Delivery with Accum® Technology
Positive
Nov 19, 2025

Defence Therapeutics announced a significant advancement in cancer treatment by enhancing the potency and reducing the toxicity of ADCs through its Accum® technology. Following successful engagements at major industry conferences, the company is set to supply its platform to ADC companies facing challenges with dosing and toxicity, aiming to transform ADC cancer therapies and establish itself as a leader in ADC drug delivery.

Business Operations and StrategyProduct-Related Announcements
Defence Therapeutics Expands Accum® Platform Evaluation After Successful ADC Conference Presentation
Positive
Nov 6, 2025

Defence Therapeutics announced a successful presentation at the World ADC Conference in San Diego, showcasing new data on its Accum® platform. The presentation highlighted how Accum® enhances intracellular delivery and payload release, boosting the potency and therapeutic index of ADCs. Following the positive response, Defence plans to expand its evaluation of Accum® across various commercial and clinical-stage ADCs, aiming to validate its potential as a universal enhancer for targeted cancer therapies. The company is engaging with industry partners to accelerate these evaluations, which could significantly impact the development of more effective cancer treatments.

Business Operations and StrategyProduct-Related Announcements
Defence Therapeutics Reports Breakthrough Preclinical Results for Accum®-Kadcyla in Breast Cancer
Positive
Nov 4, 2025

Defence Therapeutics has announced promising preclinical results for its Accum®-Kadcyla, a novel version of the ADC Kadcyla®, showing a 20-fold increase in anti-tumor efficacy in HER2-positive breast cancer models compared to Kadcyla® alone. This advancement could potentially shift current ADC therapies from second-line to first-line treatments, offering significant benefits to patients by reducing toxicity and side effects. Following these results, Defence plans to expand its program to additional tumor models and engage with potential pharmaceutical partners.

Business Operations and StrategyProduct-Related Announcements
Defence Therapeutics to Showcase ADC-Enhancing Technology at World Conference
Positive
Oct 23, 2025

Defence Therapeutics announced it will present new scientific data on its Accum® technology at the World ADC Conference in San Diego. The Accum® platform improves the intracellular delivery and endosomal escape of therapeutic payloads, addressing limitations of current ADCs and enabling higher potency with reduced off-target toxicity. This advancement could significantly enhance the therapeutic index of ADCs, positioning Defence Therapeutics as a leader in next-generation targeted therapies.

Business Operations and Strategy
Defence Therapeutics to Engage with Global Pharma Leaders at CPHI Worldwide 2025
Positive
Oct 6, 2025

Defence Therapeutics announced its participation in the CPHI Worldwide 2025, a major pharmaceutical trade fair in Frankfurt, Germany. The event presents an opportunity for Defence to engage with potential partners and the global pharma community, explore the latest trends in pharmaceutical manufacturing, and strengthen its international collaborations. The company is also hosting a networking event to foster relationships and explore partnership opportunities, which could enhance its industry positioning and stakeholder engagement.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 30, 2025