Clinical Trial ResultsPhase two interim analysis showed ratutrelvir achieved symptom resolution comparable to Paxlovid, was generally better tolerated, and had no observed symptom or virologic rebound, supporting a strong clinical profile.
Market Access And Patient EligibilityRatutrelvir's design to avoid common drug interactions that prevent a sizable portion of older and comorbid patients from receiving Paxlovid could expand the addressable patient population and uptake.
Pharmacology And Resistance ProfilePhase one and laboratory data indicated favorable safety without metabolic induction, demonstrated higher antiviral potency than the leading comparator, and retained activity against resistance-associated mutations, suggesting potential durability against emerging variants.