Financing And Partnership RiskLegacy programs will require additional financing or partnerships to progress, creating reliance on external capital or collaborators and increasing execution risk for those assets.
Legacy Pipeline DeprioritizationDeprioritization of legacy oncology programs, including amezalpat and TPST-1495, reduces near‑term upside from those assets and narrows the company's therapeutic breadth.
Shareholder DilutionExisting shareholders lose majority ownership in the combined company and face substantial dilution from the transaction structure, which may weaken investor influence and sentiment.