Clinical Hold OverhangClinical holds requiring standardized patient monitoring and immunosuppression protocols create regulatory overhang that could interrupt enrollment and delay trial progress.
Competitive Efficacy ComparisonAnalysts caution that observed protein expression increases appear smaller than some competitor reports, which could weaken competitive positioning if larger datasets do not show stronger responses.
Trial Variability And Data GapsSmall sample sizes, cases with no measurable expression, and patients lost to follow-up complicate interpretation of efficacy signals and raise uncertainty about program outcomes.