Revenue and Profit Growth (FY 2025)
Total revenues increased 5% to $17.3B; adjusted EBITDA grew 12% to $5.3B; EPS increased 19% to $2.93; free cash flow rose ~16% to $2.4B (includes $500M Sanofi milestone).
Innovative Portfolio Momentum
AUSTEDO, UZEDY and AJOVY combined reached $3.1B for the year, up ~35%; AUSTEDO $2.26B (+34%), UZEDY $191M (+63%), AJOVY $673M (+30%).
AUSTEDO Performance
AUSTEDO Q4 $725M (+40% YoY); TRx +10% and milligram volume +19%; AUSTEDO XR accounts for 60% of new patients; 2026 guidance $2.4B–$2.55B with potential to hit $2.5B ahead of plan.
UZEDY and AJOVY Strength
UZEDY Q4 $55M (+28%) with TRx volume +123%; 2026 guidance $250M–$280M. AJOVY Q4 $211M (+43%); full-year $673M (+30%); 2026 guidance $750M–$790M.
Pipeline Catalysts and External Validation
Multiple near-term catalysts in 2026: duvakitug maintenance readout H1, anti-IL-15 vitiligo data H1 and celiac H2, DARI Phase III completion by year-end, olanzapine LAI submission made and EU filing planned; external funding/partnerships (Sanofi milestone $500M; Royalty Pharma support) validate programs.
Gross Margin Improvement
Non-GAAP gross margin improved 80 bps YoY in Q4 to 56.2%; full-year gross margin 54.7% (above guidance). 2026 gross margin guidance 54.5%–55.5% reflecting portfolio mix shift.
Balance Sheet and Deleveraging Progress
Net debt reduced to ~ $13B; net debt-to-EBITDA at 2.5x (target 2.0x by 2027); finance expense expected to decline to approx. $800M in 2026; positive rating momentum (S&P upgrade, improved Moody's outlook).
Transformation Savings and Biosimilars Growth
Transformation program target $700M of net savings by 2027; $70M achieved in 2025 and on track for ~2/3 by end-2026. Biosimilars: 10 assets in market, 6 launches planned by end-2027 and target to grow biosimilars revenue by ~$400M by 2027.