Record Full-Year Revenue
Total revenues reached a record $719.0M for FY2025, driven by growth products and the Sage acquisition.
Strong Contribution from Growth Portfolio
Revenues from four growth products (Qelbree, GOCOVRI, ZURZUVAE, ONAPGO) grew 40% (company-stated) and accounted for ~76% of total revenues in Q4 2025.
ONAPGO Early Commercial Traction and Supply Progress
ONAPGO Q4 net sales of $8.9M (up from $6.8M in Q3); first-year net sales $17.3M. Prescriptions grew 29.6% and prescribers grew 28% Q4 vs Q3. Current supplier will cover 2026; guidance assumes $45M–$70M of ONAPGO net sales in 2026.
ZURZUVAE Rapid Uptake Post-Acquisition
ZURZUVAE collaboration revenues of $32.8M in Q4 and $53M for the 5-month period since the Sage close (July 31, 2025). Biogen-reported U.S. sales rose ~187% YoY and ~19% QoQ; prescribers doubled YoY and total prescriptions increased >150% YoY.
Qelbree Delivers Strong Growth and Scale
Qelbree exceeded $300M in net sales for 2025, delivering 26% growth vs 2024. Total annual prescriptions grew 21% YoY; adult prescriptions +29% and pediatric +18% in 2025. Q4 prescriptions +18% YoY.
GOCOVRI Continued Growth
GOCOVRI net sales reached $146M for 2025, up 12% YoY; total annual prescriptions reached ~67,000 (+14% YoY); Q4 net sales $38.6M with Q4 prescription growth of 16% YoY.
Non-GAAP Profitability and Adjusted Operating Results
Q4 2025 adjusted (non-GAAP) operating earnings were $48.5M (flat YoY). Full-year 2025 adjusted operating earnings were $158.7M and management provided 2026 non-GAAP guidance of $140M–$170M.
R&D Progress and Pipeline Advancement
Initiated Phase IIb SPN-820 (approx. 200 MDD adults); SPN-817 Phase IIb ongoing (target ~258 TR focal seizure patients); SPN-443 Phase I expected H2 2026. Early-stage Sage assets evaluated with select retention and partnership plans.
Strong Balance Sheet Flexibility
Cash, cash equivalents and marketable securities of ~$309M as of Dec 31, 2025; no debt and stated flexibility to pursue M&A and BD opportunities.
2026 Financial Guidance
Management expects FY2026 total revenues of $840M–$870M, combined R&D+SG&A $620M–$650M, GAAP operating income range breakeven to -$30M, and non-GAAP operating earnings $140M–$170M.