First Full Year Commercial Revenue
ARS generated $72.2 million in U.S. net product revenue in 2025 (first full commercial year) and $84.3 million in total revenue (including $9.7M collaboration and $2.4M supply revenue), demonstrating initial commercial traction.
Strong Cash Position
Year-end cash, cash equivalents and short-term investments totaled $245 million, which management states is sufficient to fund U.S. commercial expansion and programs through expected cash-flow breakeven.
Prescriber Adoption and Repeat Writing
More than 22,500 health care providers prescribed neffy by year-end 2025, with ~50% repeat writers and ~80% of prescriptions concentrated in decile 7-10 (high-volume allergists and pediatricians), indicating targeted adoption in priority accounts.
DTC Awareness Lift
Aided brand awareness increased from ~20% pre-campaign to ~60% post-campaign (a +40 percentage-point improvement). Approximately 55% of caregivers/patients recall seeing a neffy advertisement, exceeding industry norms.
Digital Conversion and Get neffy on Us Traction
Getneffy.com has facilitated ~10% of neffy prescriptions and provides virtual visits plus zero co-pay options for eligible commercially insured patients, improving conversion pathways and reducing in-office friction.
Real-World Effectiveness Data
Real-world data from the neffy Experience program showed ~90% of patients experiencing anaphylaxis were effectively treated with a single dose, consistent with injection-based epinephrine results and supporting neffy's safety and effectiveness profile.
Commercial Coverage Expansion
Management reported ~93% overall commercial coverage across plans (inclusive of those that may require prior authorization) and unrestricted Medicaid coverage in 8 states, with ongoing payer discussions to broaden access further.
Operational Plan to Increase Field Intensity
Planned salesforce expansion from 106 to 150 reps (beginning Q2 2026) to increase frequency of engagement in high-volume accounts; expansion funded via reallocation of existing commercial resources and expected to be neutral to 2026 SG&A run rate.
International and Pipeline Progress
International partners advancing regulatory approvals and partner-led launches in Europe, China, Japan and Australia in 2026; Phase IIb program for chronic spontaneous urticaria flares on track with interim data expected H2 2026 and Phase III planned to start mid-2027.