The earnings call highlighted strong clinical trial results and expansion plans with multiple Phase III trials, indicating significant progress and potential for ivonescimab in various cancer treatments. However, financial concerns and increased expenses were noted as challenges.
Company Guidance
During the Summit Therapeutics Q3 2025 Earnings and ESMO Data Update Call, significant guidance was provided regarding the company's clinical developments and financial status. The company announced the expansion of its Phase III clinical development programs, notably the global Phase III study in first-line colorectal cancer. The successful Phase III HARMONi-6 study was discussed, revealing a 4.24-month improvement in median progression-free survival for ivonescimab plus chemotherapy over tislelizumab plus chemotherapy in advanced squamous non-small cell lung cancer, with a hazard ratio of 0.60 and p-value <0.0001. The company intends to submit a Biologics License Application (BLA) for ivonescimab this quarter based on these results. Financially, Summit ended Q3 2025 with a cash position of $238.6 million, with non-GAAP operating expenses at $103.4 million, reflecting increased R&D expenses. The clinical trial expansion includes 14 Phase III trials across various solid tumors, emphasizing a strategic focus on lung, colorectal, breast, head and neck, biliary tract, and pancreatic cancers.
Positive Results from HARMONi-6 Study
The HARMONi-6 trial demonstrated a significant progression-free survival benefit for ivonescimab plus chemotherapy with a hazard ratio of 0.60 and a p-value of less than 0.0001. Median progression-free survival was 11.14 months compared to 6.90 months for the control arm, showing a difference of 4.24 months.
Expansion of Phase III Clinical Development Programs
Summit Therapeutics announced the expansion of their Phase III clinical development programs with the initiation of the global Phase III HARMONi-GI3 trial, evaluating ivonescimab in first-line unresectable colorectal cancer, expanding beyond lung cancer.
Upcoming BLA Submission for Ivonescimab
Summit plans to submit a Biologics License Application (BLA) for ivonescimab in Q4 2025 based on the results of the HARMONi study, aiming for approval in the United States.
Summit Therapeutics (SMMT) Earnings, Revenues Date & History
The upcoming earnings date is based on a company’s previous reporting, and may be updated when the actual date is announced
The table shows recent earnings report dates and whether the forecast was beat or missed. See the change in forecast and EPS from the previous year.
Beat
Missed
SMMT Earnings-Related Price Changes
Report Date
Price 1 Day Before
Price 1 Day After
Percentage Change
Oct 20, 2025
$20.99
$20.04
-4.53%
Aug 11, 2025
$28.25
$25.68
-9.10%
May 01, 2025
$24.67
$27.90
+13.09%
Feb 24, 2025
$22.12
$18.84
-14.83%
Earnings announcements can affect a stock’s price. This table shows the stock's price the day before and the day after recent earnings reports, including the percentage change.
FAQ
When does Summit Therapeutics (SMMT) report earnings?
Summit Therapeutics (SMMT) is schdueled to report earning on Mar 12, 2026, After Close (Confirmed).
What is Summit Therapeutics (SMMT) earnings time?
Summit Therapeutics (SMMT) earnings time is at Mar 12, 2026, After Close (Confirmed).
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