Record Annual Net Sales Above $11 Billion
Net sales surpassed $11.0 billion for the first time, reported at $11.1 billion with growth of ~5% at constant currencies (Remco cited underlying growth of 6%). Q4 marked the 17th consecutive quarter of sales growth.
Strong Biosimilars Momentum and Mix Shift
Biosimilars grew strongly (Richard cited 13% growth; Remco noted 18% underlying biosimilars growth) and now represent ~30% of total net sales (31% in Q4). Biosimilars contributed meaningfully to mix, driving margin expansion.
Margin Expansion and Profitability
Core EBITDA margin expanded by 160 basis points to 21.7% (from 20.1%), with core EBITDA up ~14% year-on-year. Core gross profit reached $5.6 billion with a gross margin of 50.6%.
Strong EPS and Cash Generation
Core diluted EPS grew by 33%. Management free cash flow increased by $435 million to $1.5 billion, reflecting improved operating performance and working capital discipline.
Improved Return on Invested Capital and Leverage
Core ROIC improved to 14.5% (up ~2.0–2.2 percentage points). Net debt-to-core-EBITDA improved to ~1.5x; underlying net debt (ex-FX) fell by $200 million to ~$3.1 billion (reported net debt $3.6 billion affected by FX).
Successful New Product Launches
Multiple launches: Pyzchiva (U.S. and EU auto-injector), Tyruko (EU and U.S. roll-out), Wyost and Jubbonti (first denosumab biosimilars in the U.S. and launches in EU/Canada), Afqlir (entered Europe; U.S. launch expected Q4 2026), and Enzeevu label expansion by the FDA—all positioned to contribute meaningful growth.
Strategic Acquisition and Manufacturing Investment
Acquisition of Just-Evotec Biologics Europe completed end-2025 to strengthen biologics development and continuous manufacturing capability. Investing to build an end-to-end biosimilars hub in Slovenia; CapEx ~ $700 million in 2025 and expected ~ $1.1 billion in 2026 (peak year) primarily for biosimilar capabilities.
Broad Regional Performance and Diversification
Performance was broad-based: Europe 54% of net sales and grew ~6%; International ~24% (underlying +9% for year, +14% in Q4); North America ~22% (underlying +5% for year). Volumes contributed +8% to sales, FX +2% and price erosion moderate at -3%.
Sustainability and Access Impact
Served over 1 billion patients in >100 countries and delivered $26 billion in savings to health-care systems. Emissions reductions: Scope 1 down 18%, Scope 2 down 15%, Scope 3 down 1%. SBTi targets submitted for validation.