First AI-enabled clinical proof of concept (REC-4881) in FAP
Phase 2 showed a 43% median polyp burden reduction at 4 mg QD with 75% of patients responding; durable responses observed after a three-month off-treatment period. FDA engagement on registrational pathway on track for 2026 and 18+ cohort enrollment underway.
Material partnership cash inflows and Sanofi milestone progress
Recorded over $500 million in cumulative partner upfronts and milestones to date. Sanofi collaboration delivered $100M upfront plus ~$34M in milestones accepted (total ~$134M); each small-molecule program carries potential >$300M in milestones plus tiered royalties (some up to double digits).
Extended cash runway and year-end cash balance
Year-end cash of $754 million and updated guidance extending runway to early 2028; 2026 cash operating expense guidance expected under $390 million (non-GAAP cash measure).
Significant operating expense efficiency
Achieved a 35% pro forma reduction in operating expenses year-over-year (2024 to 2025) and delivered results ~10% below prior guidance, attributed to portfolio focus, G&A optimization, and platform efficiency gains.
Chemistry and discovery throughput improvements
Synthesizing ~90% fewer compounds versus industry benchmarks (about 300–330 compounds versus ~2,500), shortening target-to-advanced-candidate timelines to ~17 months versus ~40+ months industry average (2x faster). Generated >100 million molecules in silico and produced over 10 internal development candidates.
Rapid design cycles and PI3K preclinical performance
Designed 242 compounds across 13 cycles in 10 months for the PI3K H1047 mutant-selective program; preclinical data showed dose-dependent tumor regression comparable or superior to competitors and no hyperglycemia/metabolic signals in naïve and obese diabetic animal models; IND-enabling studies ongoing with go/no-go decision in H2 2026.
Platform scale and clinical operations impact
Platform has >50 petabytes of multimodal data and 300M+ real-world lives integrated; clinical development AI platform improved enrollment rates by ~1.3x–1.6x and can accelerate study starts by up to three months through precision site/patient heat maps.
Repeatable discovery signal with Sanofi and Roche Genentech collaborations
Five lead packages delivered/accepted by Sanofi so far, illustrating repeatability; two biology maps with Roche Genentech accepted and being translated into new programs.