Strong Year-over-Year Revenue Growth
Net revenues of $58.3 million in Q1 2026, up 104% versus $28.5 million in Q1 2025; sequential growth of ~1% versus Q4 2025. Management is maintaining full-year 2026 revenue guidance of $320 million to $345 million.
Rapid Prescription Momentum and Market Penetration
Approximately 1.35 million VOQUEZNA prescriptions filled through April 17; Q1 filled ~268,000 prescriptions. Covered prescriptions grew ~91% year-over-year and total prescriptions grew ~115% year-over-year. Two of the first three weeks in April set new all-time highs for covered prescriptions.
High New-to-Brand (NBRx) Conversion Among GI Prescribers
Top 300 gastroenterology writers achieved ~45% NBRx market share versus PPIs in Q1; top 3,000 gastroenterology writers show cumulative NBRx share north of 30%. Covered NBRx grew ~11% versus Q4 2025, indicating strong new patient starts.
Sales Force Expansion and Commercial Execution
Expanded sales team with nearly 50 new reps trained and deployed; more than 290 reps in place entering Q2 and sales force alignment complete to support deeper gastroenterology coverage and increased HCP engagement.
Healthy Gross Margin and Gross-to-Net Outcome
Reported gross margin of approximately 80% for Q1. Gross-to-net discount for Q1 came in at the lower end of the company’s 55%–59% guidance range, aided by channel mix dynamics.
Expense Discipline and Reduced Cash Operating Spend Year-over-Year
Q1 cash operating expenses (excluding stock-based compensation) were $56.2 million. Year-over-year cash operating expenses declined approximately 43% versus Q1 2025, reflecting cost discipline.
Conservative Cash Usage and Solid Ending Cash Balance
Net cash usage from operations in Q1 was approximately $15 million. Cash and cash equivalents ended the quarter at about $181 million. Management expects cash on hand plus operating cash generation to be sufficient to meet obligations without an additional raise.
Clinical Development Progress — EoE Trial Enrolling Ahead of Schedule
Phase II eosinophilic esophagitis (EoE) trial is enrolling ahead of schedule with anticipated topline data in late Q4 2026 or early Q1 2027, supporting potential label/indication expansion pathway.
Resolved Data Reporting Gap
Incremental IQVIA reporting gap from prior call was resolved by mid-March and TRx numbers reported include previously un-captured prescriptions, improving visibility into prescribing trends.