Strong Volume and MRD Adoption
Processed ~924,000 tests in Q4 2025; record MRD clinical unit volume with 225,000 MRD tests in Q4. MRD clinical units grew ~56% year-over-year, and internal data estimates >50% of U.S. oncologists ordered a Signatera test in the quarter.
Robust Revenue Growth
Quarterly revenue of ~$666 million, approximately $6 million ahead of the January preannouncement and ~40% year-over-year revenue growth.
Record Gross Margin and Organic Margin Expansion
Reported gross margin of 66.9% in Q4; after removing revenue true-ups (~3% benefit), organic gross margin was 63.7%. Organic COGS efficiencies drove a sequential organic margin step-up of ~240 basis points versus Q3.
Strong Cash Generation and Balance Sheet
Generated over $107 million in cash flow in 2025 while increasing growth investments; ended with a strong balance sheet with >$1 billion in cash and securities.
Improved Working Capital / Collections
$60 million of revenue true-ups in Q4 consistent with preannouncement and DSO improved to 47 days versus 68 days in Q4 2024, reflecting accelerated cash collections and revenue cycle improvements.
2026 Financial Guidance with Continued Margin Focus
Initial 2026 guidance: revenue $2.62B–$2.70B (midpoint implying ~25% growth ex-true-ups relative to 2025), gross margin guidance 63%–65%, OpEx growth targeted ~9.5% at the midpoint with SG&A roughly stable and continued targeted R&D investments.
Product & Clinical Milestones — Tissue-Free MRD (Latitude) Submission
Submitted Latitude, a tissue-free MRD assay, to MolDX in colorectal cancer. GALAXY validation: hazard ratio 10 post-surgery and 31.9 in post-treatment surveillance; 84% longitudinal sensitivity, 97% sample-level specificity, and a 4.6-month median lead time ahead of imaging.
Technology Leap — Phased Variant Integration
Acquired and integrated phased variant technology (from Foresight). Analytically LOD95 ≈ 3 parts per 10 million and detection below 1 per 10 million; claimed 10–100x improved detection thresholds vs conventional approaches, expected to launch clinically this year and strengthen MRD sensitivity and pharma service offerings.
Significant Clinical & Publication Momentum
Multiple high-impact publications and conference milestones: IMvigor011 publication in NEJM; Fetal Focus EXPAND trial selected as an oral plenary at SMFM; strong set of bladder and head & neck MRD interventional data (e.g., SYNERGY trial showing 63% ORR and reduced high-grade toxicity).
Women's Health and Organ Health Progress
Launched 21-gene Fetal Focus single-gene NIPT (sensitivity 96%, specificity 98%) and reported meaningful new OB/GYN and MFM account traction. Organ health: Prospera enrollment completed for ACES-EMB (>300 patients) with readout mid-2027; lung study showed clinicians forgone 9-month surveillance biopsy in ~75% of patients without worse outcomes.
Signatera ASP and Pricing Momentum
Signatera average selling price (ASP) ~ $1,225 in Q4; Q4 saw ~ $20 uplift in ASP with guidance embedding roughly another $30 of ASP improvement over the near term (company previously expected an incremental $50 over time).