Biological Mechanism EvidenceElectrophysiological data showing reductions in abnormal hyperactive reticulospinal signaling in limbs provide objective support for the proposed biological mechanism of functional recovery.
Durable Functional ImprovementsLonger-term follow-up demonstrated durable and strengthening improvements in hand function and overall motor assessments after treatment cessation, indicating potential for sustained patient benefit.
Trial EnrollmentA multicenter trial design that does not require patient relocation, combined with high unmet need in spinal cord injury, should support stronger patient enrollment and reduce recruitment hurdles.