Quarterly and Annual Revenue Above Expectations
Q4 2025 revenue of $209.8M (CEO rounded to $210M) came in above the high end of the preannounced range. Full year 2025 revenue was $824.5M.
Strong Test Volume and Provider Reach
Delivered ~382,000 test results in Q4 and over 1.5 million test reports for the full year 2025, serving more than 55,000 health care providers.
Hereditary Cancer (MyRisk) Volume Growth
MyRisk oncology volume gains: 14% year-over-year growth in the affected market and 11% year-over-year growth in the unaffected market; hereditary cancer testing grew 9% in Q4 and 7% for full year 2025.
Prolaris Momentum
Prolaris revenue accelerated to 16% year-over-year growth in Q4, driven by 12% test volume growth year-over-year after recent commercial investments.
GeneSight Recovery and Provider Expansion
GeneSight volume grew 9% year-over-year in Q4, revenue of $36.6M for the quarter, and a record >38,000 ordering clinicians in Q4; secured positive coverage policies across 12 payers (including Medi-Cal) in 2025.
Profitability and Cash Generation
Q4 adjusted gross margin ~70% (70% reported), adjusted EBITDA $14.3M, adjusted EPS $0.04, and adjusted operating cash flow $17.9M; maintained access to $225M in capital.
Robust Product and Commercial Roadmap with Confirmed Guidance
Launched expanded MyRisk panel (Q4); Prolaris AI-enhanced test planned for Q2 2026; Precise MRD alpha launch for breast cancer starting next week (select centers); FirstGene analytical validation published with commercial launch planned H2 2026. Reaffirmed full year 2026 guidance: revenue $860–$880M, adjusted gross margin 68–69%, adjusted EBITDA $37–$49M. Q1 2026 revenue guidance $200–$203M (2–4% growth).