Quarterly Revenue Growth and Raised Guidance
Total company revenue of $16.3 billion in Q1, up 5% year-over-year (3% ex-FX). Management narrowed and raised 2026 revenue guidance to $65.8B–$67.0B (growth of 1%–3%, including ~1ppt FX) and raised non-GAAP EPS guidance to $5.04–$5.16 (including ~$0.10 FX benefit).
KEYTRUDA Momentum
KEYTRUDA family sales of $8.0 billion, up 8% YoY, driven by metastatic and earlier-stage uptake; KEYTRUDA QLEX debuted at $128 million in Q1 and received a permanent J-code on April 1. Q1 benefited from approximately $250 million of wholesaler purchase timing.
Strong Oncology & Regulatory Progress
Multiple pipeline and regulatory milestones including FDA approval of IDVYNSO for virologically suppressed HIV-1, FDA priority review for I-DXd (PDUFA Oct 10), approvals/priority reviews for KEYTRUDA combinations (e.g., ovarian cancer, MIBC with action date Aug 17), and further WELIREG submissions (PDUFA dates Jun 19 and Oct 4). Several Phase III readouts expected over the next 18 months.
Commercial Launches and Longer-Term Opportunity
Initial launches of 20+ new products underway with management citing a potential commercial opportunity of over $70 billion by the mid-2030s from these growth drivers. Organizational changes (new business units) and AI partnerships (Google Cloud, Tempus, Mayo Clinic) intended to accelerate commercialization and R&D productivity.
Vaccines & Pneumococcal Growth
CAPVAXIVE (pneumococcal) sales of $142 million in Q1, up 31% YoY, driven by uptake in certain markets and increased U.S. retail/nonretail demand.
Animal Health Strength
Animal Health sales increased 6% YoY: Livestock +8% due to higher ruminant/poultry demand and pricing; Companion animal +4% driven by new product launches and price. Introduced NUMELVI for canine allergic dermatitis.
Operational and Capital Allocation Actions
Non-GAAP gross margin ~81.9% (guidance ~82%). Company remains committed to dividend growth, on pace for roughly $3 billion of share repurchases in 2026, and retains investment-grade credit capacity for additional BD.