Subscriber Growth and Engagement
Active subscribers increased 16% year-over-year to ~322,000 (nearly 323,000) with over 13,000 net new subscribers added in Q4 (largest quarterly net gain in 2025). LifeMD onboards ~1,200 new patients per day and reported >120,000 unique daily website visitors.
Revenue Growth
Q4 revenue of $46.9M, up 4% year-over-year; full-year 2025 revenue $194.1M, up 25% versus 2024.
Profitability and Margin Expansion
Q4 gross margin expanded to 87.1% (up 570 basis points YoY) with gross profit of $40.8M (+11% YoY). Full-year gross profit was $166.3M (+25% YoY). Adjusted EBITDA improved to $4.8M in Q4 (from $1.1M prior year) and $15.3M for the full year (from $3.7M prior year).
Strong Balance Sheet
Exited Q4 with $36.8M in cash and no debt, providing financial flexibility to invest in growth initiatives.
Weight Management Momentum (GLP-1)
Record demand in weight management with new sign-ups approaching ~700/day in Q1 2026; over 80% of new patient sign-ups went on branded therapy in early 2026. Customer acquisition costs (CAC) in the GLP-1 business declined sequentially (~4% reported) even as volumes doubled.
Pharmacy and Fulfillment Expansion
Affiliate pharmacy licensed in all 50 states, processing ~20,000 prescriptions per month. In-house fulfillment approaching ~70% of volume, yielding an estimated 150–200 basis point margin improvement from internal fulfillment. Licensed 503-A compounding operation enables personalized medications at scale.
Strategic Partnerships and Product Launches
Launched oral Wegovy via collaboration with Novo Nordisk and integrated Wegovy offerings into RexMD. One of the few virtual providers integrated with Novo Nordisk and Eli Lilly affiliated pharmacies; pipeline opportunities with other pharma partners.
Infrastructure & AI Investments
Investing heavily in AI (dedicated team; planned AI clinical decision support in H1 2026), launched a 30-state beta virtual cardiology program leveraging AI-supported intake, and embedding automation to improve G&A efficiency and scale care delivery.
Benefits Coverage Expansion
Platform currently covers >110M lives through payer contracts and expects to grow to >220M lives by end of Q2 2026 via an expanded partnership; insurance enablement has historically reduced CAC by up to 30%+.
Forward Guidance
Q1 2026 revenue guidance of $48M–$49M (expected adjusted EBITDA loss $4M–$5M due to investment). Full-year 2026 revenue guidance of $220M–$230M with adjusted EBITDA $12M–$17M. Company expects Q4 2026 annualized run rates >$250M revenue and >$25M adjusted EBITDA.