Extended Cash Runway and Financing Actions
Cash position of $55.8M as of Dec 31, 2025; $5.4M in proceeds from warrants exercised in March 2026; $21M gross proceeds from an ATM block trade in November 2025; $5M milestone payment from Roche/Genentech. Management expects these resources (including the March warrant proceeds) to fund operations into Q2 2028.
Successful Go/No-Go on Islet Cell Scale-Up at 0.5 L
Achieved the initial internal go/no-go milestone for the islet cell research initiative by demonstrating reproducible 5D (2D control + 3D volumetric) manufacturing at 0.5 liter scale multiple times. Company is moving to evaluate translation to multi-liter vessels as the next step toward 80-liter bioreactor scale required for commercial doses.
AlloSCOPE Manufacturing Validation (GMP Cell Banking & Clinical Use)
Established GMP master and working cell banks and generated product used in an FDA-cleared clinical trial; hundreds of identical vials in banks provide confidence in repeatability and potential to scale to millions of vials (millions of doses / trillions of cells) — a core technical and commercial differentiator.
OpRegen Clinical Signal and Partner Momentum
Independent analysis (Roche/Genentech) observed that a single OpRegen dose can provide visual improvement lasting at least 3 years in patients treated at target location. Genentech expanded GAlette study sites from ~7 to 17 (addition of 9 new sites in 2025), and OpRegen has RMAT designation; Lineage received a $5M development milestone from Roche/Genentech.
ReSonance (ANP1) Partnership and Rapid Internal Progress
Internally developed auditory neuronal program (ReSonance/ANP1) advanced from conception to preclinical testing within one year and secured a partnership with William Demant Invest expected to fund planned preclinical development through IND — demonstration of the AlloSCOPE platform’s speed and partner interest.
OPC1 Progress in Spinal Cord Injury Program
DOSED study enrollment ongoing; first chronic spinal cord injury patient treated with no significant safety events at 6-month follow-up and device performed as planned. Expanded DOSED to a second clinical site (Rancho Research Institute / Rancho Los Amigos).
Revenue Growth Driven by Collaboration Milestones
Q4 2025 total revenues of ~$6.6M, up $3.7M year-over-year (approximately +128% YoY). Full-year 2025 revenues of $14.6M, up $5.1M YoY (approximately +54% YoY), primarily driven by collaboration revenue (Roche milestone) and the new WDI research collaboration.