AlloSCOPE Manufacturing Platform Expansion
Successful expansion of the AlloSCOPE platform with two-tiered banking (master → working → clinical) demonstrated reproducible steps and FDA-cleared final product; company cites mathematical potential for millions of vials and cost-per-dose potentially in the hundreds of dollars, supporting allogeneic off-the-shelf strategies.
Launch of COR1 Corneal Endothelial Cell Program
Launched COR1 (wholly owned) for corneal endothelial disease (Fuchs and other dystrophies); preclinical development produced cryopreservable off-the-shelf corneal endothelial cells that met initial internal identity, morphology and functional criteria and will proceed to translational models with the goal of IND-enabling work.
OpRegen Partner Momentum and Long-term Data
Roche/Genentech analysis showed vision gains persisted at least 3 years after single administration in some patients; partner recently opened 11 new clinical sites (bringing GAlette study to 17 sites), indicating increased partner investment and operational scale for OpRegen.
ILT1 Manufacturing Milestone
Met first internal milestone for ILT1 by demonstrating a highly homogenized, scalable, fully suspension-based process for undifferentiated pluripotent cells at 0.5-liter scale and progressed into larger multi-liter formats to address islet-scale feedstock requirements.
OPC1 Delivery Device and Clinical Progress
DOSED trial (OPC1 delivery device) has performed as expected with no unexpected procedure/product/device-related adverse events or significant design changes; study expanded to a second site (Rancho Research Institute) and the first chronic SCI participant is approaching 1-year follow-up.
ReSonance Partnership and Manufacturing Runs
ReSonance (auditory neuronal cell program) partnership with William Demant: completed 3 engineering runs and preparing for GMP manufacturing; Demant committed up to $12M to preclinical activities (approx. two-thirds as reimbursement to Lineage).
Strategic SAB Appointment and Clinical Leadership Hire
Formed Scientific Advisory Board with founding member Dr. Joachim Froebus and hired Dr. Priyantha Harath as SVP & Head of Clinical — strengthening late-stage development, regulatory, and clinical execution capabilities.
Cash Position and Potential Near-Term Funding
Cash of $53.4M as of 03/31/2026, expected to fund operations into 2028; potential additional liquidity includes ~ $32M from existing warrants (contingent/accelerated on OpRegen advancement disclosure) and eligibility for up to $615M of Roche-Genentech milestone payments under collaboration.