Regulatory And Commercial RiskThe unexpected safety signal and changes to KROS’ Phase 2 TROPOS study of cibotercept in pulmonary arterial hypertension significantly increases the clinical, regulatory, and commercial risk for this asset.
Safety ConcernsSafety concerns with the second lead asset, cibotercept, following observation of pericardial effusion in their ongoing Phase 2 study, led to a significant pullback in the stock.
Uncertain Path ForwardCibotercept's increasingly uncertain path forward and the program's cost are considered a clearing event, removing a potential distraction.