Positive Outlook for Insmed: Promising Product Pipeline and Favorable Market Position Justify Buy RatingKey takeaways from the call: Thus far Dr. Lascano estimates that he has prescribed Brinsupri to 20-25 patients of his 150-160 total NCFB patients. That said, Dr. Lascano thinks most of his patients did not begin therapy by the end of September. BiRCh trial for brensocatib in CRSsNP , he believed a 10-15% reduction from baseline on the sTSS score would be clinically meaningful. Further he noted that theoretically brensocatib may be less effective in patients with higher eosinophil levels. While this trend was not observed in the ASPEN trial for NCFB, he noted that CRS is more likely to be driven by eosinophils than NCFB. Expert Background Dr. Jorge Lascano, MD, is a (10/2011- present). His clinical interests include cystic fibrosis, alpha-1, non-cystic fibrosis bronchiectasis, and COPD.