BRINSUPRI Strong Sequential Launch Growth
BRINSUPRI delivered 44% sequential growth in Q1 off an already strong prior-quarter baseline; the company noted $350M in combined revenue in the first two full quarters (Q4/2025 + Q1/2026) and reiterated full-year 2026 BRINSUPRI guidance of at least $1.0B.
High Payer Approval and Fast Authorization
Approval rate for patients processed through specialty pharmacies has been nearly 90% since launch, with time to payer approval under one week for the majority of patients—well ahead of internal benchmarks.
Strong Patient Engagement and Adherence Metrics
More than 80% of BRINSUPRI patients enrolled in the inLighten patient support program; refill cadence is nearly every 30 days versus an industry benchmark of ~37 days, and continuation rates are tracking slightly above 6-month statin benchmarks (~70%).
Expanding Prescriber Base
Cumulative prescribers exceeded 5,000 by the end of Q1, representing over 25% of U.S. pulmonologists; >20% of BRINSUPRI prescribers have written prescriptions for at least 5 patients, and many low-volume prescribers are increasing their prescribing depth.
ARIKAYCE Phase IIIb ENCORE Positive Results
ENCORE met its patient-reported respiratory symptom score primary endpoint (statistically significant) and showed earlier, greater and durable culture conversion (>80% conversion with earlier treatment vs ~30% in prior refractory CONVERT study), with better tolerability and lower discontinuation in the earlier-treatment population.
TPIP Late-Stage Progress
Opened first site in the Phase III PALM PAH study; PALM-ILD has randomized patients across 7 countries; 4 Phase III TPIP trials underway/planned (PAH, PH-ILD, PPF, IPF). Open-label extension (PAH) showed ~25% of participants uptitrated above 640 mcg and 7 of 91 reached the 1,280 mcg dose; OLE data expected in Q3 2026.
Solid Financial Position and Path to Cash Flow Positivity
Cash, cash equivalents and marketable securities were approximately $1.2B at quarter-end; underlying cash burn for the quarter was in the recent historical range, and the company expects to achieve sustainable cash flow positivity in 2027 without needing additional capital (assuming no expansion of expense base via BD).
Improved Gross Margin Profile
Cost of product revenues in Q1 was $47.4M, representing 15.5% of revenues—a lower percentage than historical performance attributed to BRINSUPRI's positive contribution to gross margin.