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BioLineRX Ltd. (IL:BLRX)
:BLRX
Israel Market
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Bioline Rx (BLRX) AI Stock Analysis

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IL:BLRX

Bioline Rx

(BLRX)

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Neutral 46 (OpenAI - 4o)
Rating:46Neutral
Price Target:
2.00
▲(11.11% Upside)
The overall stock score is primarily influenced by financial performance challenges, including profitability and cash flow issues. Technical indicators suggest bearish momentum, while valuation metrics are weak due to negative earnings. The earnings call provided some positive strategic insights, but operational reductions offset these gains.
Positive Factors
Strategic Joint Venture
The joint venture with Hemispherian to develop GLIX1 for glioblastoma expands BioLineRx's pipeline and leverages expertise in DNA damage response, potentially enhancing long-term growth prospects in the oncology market.
Patent Protection
The patent protection for GLIX1 until 2040 ensures a competitive advantage and secures long-term revenue potential from this innovative cancer treatment.
Cash Position and Financial Health
A strong cash position provides financial stability and supports ongoing R&D and operational activities, crucial for sustaining long-term growth and development efforts.
Negative Factors
Decreased R&D Expenses
Reduced R&D spending may limit future innovation and development capabilities, potentially impacting the company's ability to sustain its competitive edge in the long term.
No Sales and Marketing Expenses
The elimination of sales and marketing expenses may hinder the company's ability to effectively commercialize its products, impacting long-term revenue growth and market presence.
High Leverage and Financial Instability
Increased leverage and negative equity returns highlight financial instability, posing long-term risks to cash flow and operational flexibility if not addressed.

Bioline Rx (BLRX) vs. iShares MSCI Israel ETF (EIS)

Bioline Rx Business Overview & Revenue Model

Company DescriptionBioLineRx Ltd., a clinical-stage biopharmaceutical development company, focuses on oncology. The company develops Motixafortide, a peptide, which has completed Phase 3 clinical trials for the treatment of autologous stem cell mobilization and Phase 2a clinical trials for the treatment of pancreatic cancer; and that is in Phase 2 clinical trials for the treatment of metastatic pancreatic adenocarcinoma patients, and Phase 1b clinical trials in patients with acute respiratory distress syndrome secondary to COVID-19 and other respiratory viral infections, as well as for the treatment of solid tumors and acute myeloid leukemia. It is also developing AGI-134, an immuno-oncology agent, which is in Phase 1/2a clinical trials for the treatment of solid tumors; and BL-5010, a customized, proprietary, pen-like applicator for the non-surgical removal of skin lesions. The company has collaboration agreement with MSD for the cancer immunotherapy field; MD Anderson Cancer Center to investigate the combination of Motixafortide with KEYTRUDA (pembrolizumab) in pancreatic cancer; and licensing arrangement with Perrigo Company plc for over-the-counter sale of BL-5010. BioLineRx Ltd. was incorporated in 2003 and is headquartered in Hevel Modi'in, Israel.
How the Company Makes MoneyBioline Rx generates revenue through several key streams, primarily from the development and commercialization of its therapeutic candidates. The company engages in strategic partnerships and collaborations with larger pharmaceutical firms, which often involve upfront payments, milestone payments based on development progress, and royalties on future sales of products. Additionally, Bioline Rx may receive funding through government grants or research contracts aimed at advancing its clinical programs. The successful development and eventual market approval of its drug candidates are critical for the company’s revenue growth, as they position the firm to benefit from product sales and licensing agreements.

Bioline Rx Earnings Call Summary

Earnings Call Date:Nov 24, 2025
(Q3-2025)
|
Next Earnings Date:Mar 12, 2026
Earnings Call Sentiment Neutral
The earnings call highlighted BioLineRx's strategic joint venture for glioblastoma treatment and robust financial health. However, decreased R&D and marketing expenses indicate reduced operational activities following out-licensing agreements. The sentiment is balanced with significant potential in new cancer treatments offset by reduced operational scope.
Q3-2025 Updates
Positive Updates
Joint Venture with Hemispherian
BioLineRx established a joint venture with Hemispherian to develop GLIX1, an innovative molecule for glioblastoma treatment. This partnership leverages BioLineRx's clinical and regulatory success with Hemispherian's expertise in DNA damage response research.
GLIX1 Development and Market Potential
GLIX1, a first-in-class oral molecule, targets DNA damage response in cancer cells. The FDA cleared its IND in August, and a Phase I/IIa trial is planned. The glioblastoma market is expected to be over $3.7 billion in the U.S. and Europe by 2030.
Patent Protection for GLIX1
A notice of allowance for a key patent covering GLIX1 was received, extending protection until 2040. Additional patents cover its use alone and in combination with anticancer agents, ensuring broad protection across multiple regions.
Cash Position and Financial Health
BioLineRx ended the third quarter with $25.2 million in cash, sufficient to fund operations into the first half of 2027. This financial stability is bolstered by potential royalties and milestone-driven revenue.
Positive Results for Motixafortide in Sickle Cell Disease
Final positive results for a Phase I trial of motixafortide in sickle cell disease will be presented at the ASH Annual Meeting. The trial demonstrated robust stem cell mobilization and could expand access to curative treatments for these patients.
Negative Updates
Decreased Research and Development Expenses
R&D expenses decreased from $2.6 million to $1.7 million year-over-year, primarily due to a decrease in headcount and lower expenses related to motixafortide after out-licensing.
No Sales and Marketing Expenses
Sales and marketing expenses dropped to zero from $5.5 million in the previous year, reflecting the shutdown of U.S. commercial operations post the Ayrmid out-licensing transaction.
Net Loss Reduction
Net loss for the third quarter of 2025 was $1 million compared to $5.8 million in the previous year, reflecting reduced operational activity and expenses.
Company Guidance
During the BioLineRx Third Quarter 2025 Financial Results Conference Call, the company provided guidance on several key initiatives and financial metrics. BioLineRx highlighted its joint venture with Hemispherian to develop GLIX1, a first-in-class oral small molecule for glioblastoma treatment, with plans to initiate a Phase I/IIa trial in early 2026 and anticipate data from the Phase I portion in the first half of 2027. The company holds a 40% stake in the JV, anticipated to increase to 70% with further investment. Financially, BioLineRx reported $25.2 million in cash and equivalents, sufficient to fund operations into the first half of 2027, and generated $0.4 million in royalty revenue from APHEXDA sales. The call also covered the ongoing development of motixafortide, with a Phase IIb trial in pancreatic cancer and potential expansion into sickle cell disease.

Bioline Rx Financial Statement Overview

Summary
Bioline Rx is experiencing revenue growth, indicating potential market demand. However, significant challenges in profitability and cash flow management persist. High leverage and negative equity returns highlight financial instability, posing risks if not addressed.
Income Statement
20
Very Negative
The company showed a significant increase in total revenue from 2023 to 2024, which is a positive sign of growth. However, the net profit margin remains negative due to substantial net losses, indicating ongoing financial challenges. The EBIT and EBITDA margins are also negative, reflecting inefficiencies in operations. Overall, while revenue growth is promising, profitability remains a concern.
Balance Sheet
35
Negative
The debt-to-equity ratio increased, indicating higher leverage, which could be risky. The return on equity remains negative due to net losses, pointing to poor returns for shareholders. The equity ratio has decreased, suggesting reduced financial stability. Although the company has a strong asset base, the increased liabilities and negative equity returns are significant weaknesses.
Cash Flow
25
Negative
The operating cash flow is negative, underscoring cash flow challenges. Free cash flow has also significantly declined, reflecting poor cash management. The operating cash flow to net income ratio is negative, suggesting inefficiencies in converting income into cash. Despite some cash inflows from financing activities, the company struggles to generate positive cash flow, which could hinder its ability to fund operations.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue17.25M28.94M4.80M0.000.000.00
Gross Profit10.23M19.68M1.11M0.000.000.00
EBITDA1.97M3.92M-57.09M-28.50M-24.07M-21.99M
Net Income-7.82M-9.22M-60.61M-20.75M-28.14M-30.93M
Balance Sheet
Total Assets43.27M38.91M63.92M76.38M81.39M47.29M
Cash, Cash Equivalents and Short-Term Investments28.16M19.56M42.99M51.08M57.13M22.59M
Total Debt12.60M15.04M11.59M12.32M4.65M7.68M
Total Liabilities23.20M25.45M50.70M25.54M13.30M25.26M
Stockholders Equity20.07M13.46M13.22M50.84M68.09M22.03M
Cash Flow
Free Cash Flow-21.20M-43.93M-22.91M-26.56M-23.67M-23.21M
Operating Cash Flow-21.20M-43.87M-22.61M-26.24M-23.57M-23.21M
Investing Cash Flow9.45M29.37M1.44M4.01M-38.22M16.67M
Financing Cash Flow8.72M20.66M15.06M20.44M57.75M17.87M

Bioline Rx Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.80
Price Trends
50DMA
2.03
Negative
100DMA
2.17
Negative
200DMA
2.15
Negative
Market Momentum
MACD
-0.06
Negative
RSI
42.03
Neutral
STOCH
58.33
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For IL:BLRX, the sentiment is Negative. The current price of 1.8 is below the 20-day moving average (MA) of 1.86, below the 50-day MA of 2.03, and below the 200-day MA of 2.15, indicating a bearish trend. The MACD of -0.06 indicates Negative momentum. The RSI at 42.03 is Neutral, neither overbought nor oversold. The STOCH value of 58.33 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for IL:BLRX.

Bioline Rx Risk Analysis

Bioline Rx disclosed 43 risk factors in its most recent earnings report. Bioline Rx reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Bioline Rx Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
46
Neutral
52.22M-0.77-42.69%88.04%
43
Neutral
51.22M
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
IL:BLRX
Bioline Rx
1.80
-6.20
-77.50%
IL:XTLB
Xtl Bio
2.80
-3.60
-56.25%
IL:CBI
Clal Biotech
32.30
-3.60
-10.03%
IL:CANF
Can Fite Bio
1.00
-1.70
-62.96%
IL:BOLT
Biolight
346.80
-181.60
-34.37%
IL:KDST
Kadimastem
2,794.00
1,497.00
115.42%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 25, 2025