GLIX1 First‑In‑Human Trial Initiated and First Patient Dosed
Phase I/IIa first‑in‑human trial of GLIX1 for glioblastoma (GBM) initiated; first patient dosed at NYU Langone. Trial Phase I expected to recruit up to 30 recurrent GBM/high‑grade glioma patients to establish MTD/recommended dose based on safety, PK/PD and preliminary efficacy. Periodic updates planned in H2 2026 with full dose escalation results expected in 2027.
Compelling Preclinical GLIX1 Data Supporting BBB Penetration and Efficacy
New preclinical data show robust dose‑dependent tumor growth inhibition and survival benefit in multiple orthotopic CDx GBM models; GLIX1 demonstrated robust antitumor activity in a temozolomide‑resistant PDX where temozolomide showed no effect. GLIX1 crosses the blood‑brain barrier and restores TET2 activity, supporting development in GBM and other cancers and rationale for combinations with PARP inhibitors.
Scientific Visibility at ASCO
Two GLIX1 abstracts accepted for online publication at ASCO highlighting the preclinical dataset and mechanistic rationale, increasing scientific engagement and external validation of the program.
Motixafortide (PDAC) — Ongoing Randomized Phase IIb Trial
BioLineRx retained rights to develop motixafortide in PDAC; Columbia University is executing the randomized Phase IIb CheMo4METPANC trial in combination with cemiplimab + standard chemotherapy. Enrollment is reported to be tracking well and a prespecified interim futility analysis is planned when 40% of PFS events are observed (anticipated later in 2026).
Commercial Traction for APHEXDA
Ayrmid reported APHEXDA sales of $2.5M in Q1 2026 vs $1.4M in Q1 2025, an increase of approximately 78.6%, resulting in $0.5M of royalty revenue to BioLineRx. Management views this as meaningful early commercialization momentum.
Revenue Increase Year‑over‑Year
Reported revenues of $0.5M for Q1 2026 compared with $0.3M in Q1 2025, an increase of $0.2M (+66.7%), driven primarily by higher royalties from APHEXDA commercialization.