Strong Top-Line Growth
Q4 revenue increased 14% reported and 12% organically; full-year 2025 organic revenue growth was 10%. CAG Diagnostics recurring revenues grew 10% organically in Q4 and 8% organically for the full year. US CAG recurring revenues rose 9% organically in Q4, driven by ~4% net price improvement and ~5% volume growth.
Record Premium Instrument Placements and Installed Base Expansion
Q4 placements of premium instruments totaled 6,567, up 42% year-over-year; full-year placements were ~22,500. InVue DX placements were nearly 6,400 for the year. Global premium instrument installed base expanded ~12% year-over-year and the Catalyst installed base reached ~78,000 units.
Strong Profitability and Cash Generation
Full-year operating margin was 31.6%, up 90 basis points on a comparable basis. Q4 operating profit grew 21% reported (17% comparable). Q4 EPS was $3.08 (+17% comparable) and full-year EPS was $13.08 (+14% comparable). Free cash flow for 2025 was $1.1 billion (100% of net income). The company repurchased $1.2 billion of shares (2.4M shares) and reduced diluted shares outstanding by 2.7% year-over-year.
Meaningful Product Innovation and Commercial Momentum
Multiple launches and expansions (InVue DX, CancerDx, Catalyst Cortisol, Catalyst pancreatic lipase, advanced radiography system) materially contributed to adoption and economic value. InVue DX instrument revenue contributed over $75 million in 2025 and supported roughly 200 basis points of company growth. CancerDx reached nearly 6,000 customers and will add mast cell tumor detection mid-2026.
Recurring Software and SaaS Momentum
Cloud-based PIMs and other software delivered double-digit recurring revenue growth in Q4. Velo users grew ~40% sequentially and nearly tripled year-over-year. The company closed the year with record quarterly bookings and growing ARR, supporting cross-sell and higher utilization.
Reference Lab and International Strength
Global reference lab revenues expanded 9% organically in Q4, aided by volume growth and competitive submissions (~18%). International CAG Diagnostics recurring revenue grew 12% organically in Q4, with strong international instrument growth and double-digit international consumable gains.
Confident 2026 Financial Outlook
Full-year 2026 guidance: revenue $4.632B–$4.72B (+7.6%–9.6% reported; 7%–9% organic), CAG Diagnostics recurring revenue growth targeted at 8%–10% organic, reported operating margin guidance 32%–32.5%, EPS $14.29–$14.80 (10%–14% comparable), and free cash flow conversion outlook of 85%–95% of net income.