Strong bookings and commercial momentum
Net bookings of $2.9B in Q4, up 19% year‑over‑year; gross bookings of $3.2B; direct‑fee book‑to‑bill of 1.36x. RFP flow increased in the low double digits and biotech win rates improved by ~5 percentage points sequentially. Cancellations fell to $365M in the quarter, meaningfully lower than elevated levels earlier in the year.
Revenue beat and pass‑through strength in Q4
Q4 revenue of $2.1B, +2.5% year‑over‑year and +1.3% sequentially; Q4 revenue was approximately $100M higher than the midpoint expectation due largely to pass‑through revenue coming in >$150M higher than anticipated.
Solid cash generation and shareholder returns
Q4 operating cash flow of $234.2M and Q4 free cash flow of $174.8M; full‑year free cash flow of $862M. Ended Q4 with $647.3M cash and $3.4B debt (net debt ~$2.8B) and leverage of 1.8x net debt / adj. TTM EBITDA. Significant share repurchases of $750M at an average price of $167.
Strategic portfolio moves and capability investments
Completed divestiture of Symphony Health (reduces FY revenue by ~2%) while retaining access to broader data assets via partner; expanded lab services (added >100 new biomarker assays); opened new Phase I clinic in San Antonio (130+ beds) and satellite centers; launched partnership with Advarra and continued investment in AI capabilities (Orbis, CRA and contracting agents) to drive productivity and differentiation.
2026 guidance with expected margin progression
Issued FY2026 guidance of revenue $7.85B–$8.15B and adjusted EPS $10.00–$11.00. Management indicated midpoint implies an approximate 16.5% EBITDA margin for 2026 and expects sequential margin improvement through the year, exiting at a higher run‑rate.