Record Quarterly and Annual Financial Performance
Q4 2025 revenue of $826.4M (+25.7% YoY, +24.7% constant currency) and full year 2025 revenue of $2.939B (+16.7% as-reported, +16.2% constant currency); Q4 non-GAAP EPS $1.28 (+52.1% YoY) and full year non-GAAP EPS $3.98 (+30.8% YoY).
Strong Base Business Growth
Q4 base business revenue $726.7M (+10.6% YoY) and consolidated base business organic growth in H2 2025 of 8.8%; U.S. Spine grew ~10% in Q4 with 48 consecutive weeks of growth, indicating durable above-market momentum.
Enabling Technologies Momentum
Q4 Enabling Technologies sales $55.6M (+18.5% YoY), achieved record sales in dollars and units for the capital portfolio and ExcelsiusGPS robotic system; pipeline deals closed in Q4 after earlier elongation.
Trauma and Product Launch Success
Trauma business grew ~27% in Q4 (26.8% reported) driven by legacy trauma uptake and demand for new launches such as the ANTHEM elbow plating system which has exceeded expectations.
Margin Expansion and Profitability
Adjusted gross profit margin expanded to 69.2% in Q4 2025 (vs. 67.1% prior year); legacy Globus adjusted EBITDA margin reached 35.7% in Q4 and consolidated adjusted EBITDA margin was 33.9%; full year adjusted EBITDA 31.3%.
Synergy Execution Outperforming Plan
Actioned $200M of NuVasive synergies (target $170M) ahead of schedule by ~$30M and achieved sequential improvements across the P&L; free cash flow generation increased ~150% from $81.8M (Q4 2023) to $202.4M (Q4 2025).
Nevro Integration and Accretion
Nevro added $293.6M revenue for the full year and $99.7M in Q4 with a stand-alone adjusted EBITDA margin of 21.2% in Q4; Nevro became EPS accretive within the first 9 months post-acquisition, 15 months ahead of initial guidance.
Improving GAAP Metrics and Debt Reduction
GAAP gross margin improved to 65.7% in Q4 (vs. 57.2% prior year), driven by lower inventory step-up amortization; fully repaid $450M convertible debt assumed in merger, reducing interest expense.
Capital Allocation and Shareholder Returns
During 2025 repurchased ~4.3M shares for $300.5M and repurchased $45M in Q4; $390M of share repurchase authorization remains under a $500M program while prioritizing internal investment and CapEx (guidance 5-6% of sales).
2026 Financial Guidance Upheld and EPS Raised
Reaffirmed 2026 revenue guidance of $3.18B to $3.22B (implied growth 8.2%–9.6%) and increased full-year non-GAAP EPS guidance to $4.40–$4.50 (implied growth 10.6%–13.1%), reflecting confidence in continued margin expansion.