Strong year-end cash position
Financial investments and cash & cash equivalents totaled approximately EUR 2,998 million at December 31, 2025 (c. EUR 3.0 billion), providing significant strategic flexibility for business development.
Return to operating profit (non-recurring driver)
Total operating profit from continuing operations of EUR 295.1 million in 2025 versus an operating loss of EUR 188.3 million in 2024 — a swing of EUR 483.4 million largely driven by the one-time release of deferred revenue related to the OLCA (EUR 1,069 million).
Release of deferred income (OLCA)
Recognition of EUR 1,069 million of remaining deferred income associated with the Gilead OLCA after assessing no remaining obligations, which materially improved 2025 operating profit; management noted no expected cash tax impact from this recognition.
Positive Phase II topline for GLPG3667 (TYK2) in dermatomyositis
GLPG3667 met the primary endpoint in the dermatomyositis Phase II study with statistically significant clinical benefit and meaningful improvement on secondary measures versus placebo; management is evaluating strategic options (including partnerships) to accelerate development.
Experienced new leadership and board refresh
New management team assembled with strong business development and deal expertise; five new board directors added with transaction, capital allocation and operating experience to execute the new strategic direction.
Focused, disciplined business-development strategy with Gilead collaboration
Company is prioritizing clinically de-risked opportunities (primarily immunology & inflammation and oncology), emphasizing disciplined capital allocation; Gilead remains a strategic partner that can potentially contribute to deal economics and development spend and thus extend the effective purchasing power beyond Galapagos' cash base.
Improved currency mix and interest yield rationale
Company increased USD exposure (now approximately 72% USD / 28% EUR of cash and financial investments) to align with expected BD activity and U.S. cost base and to capture higher dollar interest rates (management cited ~4% USD vs ~2% EUR yields).
Lowered wind-down restructuring range
One-time restructuring cash impact for 2026 reduced by EUR 25 million from the prior guidance range: new range EUR 125–175 million (previously EUR 150–200 million).