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Tissue Regenix Group PLC (GB:TRX)
LSE:TRX

Tissue Regenix (TRX) AI Stock Analysis

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GB:TRX

Tissue Regenix

(LSE:TRX)

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Neutral 49 (OpenAI - 4o)
Rating:49Neutral
Price Target:
7.00p
▼(-3.45% Downside)
Tissue Regenix faces significant financial and operational challenges, reflected in its negative earnings and reliance on external funding. Technical indicators suggest bearish momentum, and recent corporate events highlight financial instability. While there are strategic efforts to improve, the immediate outlook remains cautious.
Positive Factors
Intellectual Property Strength
Securing an EU patent and MDR certification enhances Tissue Regenix's competitive edge by protecting its technology and ensuring compliance with stringent medical regulations, which can facilitate market expansion and product adoption.
Product Line Expansion
The increase in orders for demineralized bone matrix products indicates growing demand and acceptance in the market, which can drive revenue growth and strengthen the company's position in the regenerative medicine sector.
Growth in dCELL Business
The 10% growth in the dCELL business demonstrates successful market penetration and product effectiveness, suggesting a robust segment that can contribute to long-term revenue stability and expansion opportunities.
Negative Factors
Revenue Decline
The decline in group revenues indicates challenges in maintaining sales momentum, which could affect the company's ability to achieve profitability and sustain operations without strategic adjustments.
Regulatory Challenges
Regulatory delays can hinder product distribution and revenue generation, posing risks to the company's market access and operational efficiency, which are critical for long-term growth and stability.
Financial Strain
Financial strain from reduced revenues and profitability increases reliance on external funding, which can limit financial flexibility and pose risks to the company's ability to invest in growth initiatives.

Tissue Regenix (TRX) vs. iShares MSCI United Kingdom ETF (EWC)

Tissue Regenix Business Overview & Revenue Model

Company DescriptionTissue Regenix Group plc, a medical technology company, develops and commercializes platform technologies in the field of tissue engineering and regenerative medicine in the United States and internationally. It operates through BioSurgery, Orthopaedics & Dental, and GBM-V & Cardiac divisions. The company provides dCELL technology, a soft tissue decellularisation process that removes DNA and cellular material from animal and human soft tissue to repair diseased or damaged body parts; and BioRinse technology, a natural bone filler solution for osteoinductive to stimulate and regenerate native bone growth. In addition, the company provides DermaPure, a decellularised dermal allograft for reinforcement, repair, and replacement of damaged or inadequate integumental tissue and other homologous uses of human integument; and SurgiPure XD, Decellularised porcine dermal reconstructive tissue matrix for the repair of hernias and body wall defects. Further, it offers OrthoPure XT, a scaffold to replace the damaged tissue that will re-populate with the patient's own cells; ConCelltrate 100, a verified osteoinductive bone matrix; MatrixCellect 100, a demineralised bone matrix (DBM) for orthopaedic; Matrix IQ Dermis, a human-derived dermal graft, which is decellularised to remove cellular components and preserve the biological properties that promote revascularisation, repair, and augmentation of damaged tissue; and Matrix OI FlexIt, a thin pliable demineralised cortical allograft bone sheet. Additionally, the company provides DentalFix, a mineralized particulate allograft that offer osteoconductive properties of natural bone; CardioPure products; Matrix OI 100 DBM for non-structural bone-grafting; Matrix OI Strips and Blocks, a stem cell containment human scaffold; AmnioWorks for ophthalmology and wound covering; and sports medicine products. The company was incorporated in 2006 and is based in Garforth, the United Kingdom.
How the Company Makes MoneyTissue Regenix generates revenue primarily through the sale of its tissue-based products to hospitals, clinics, and other healthcare providers. The company's revenue model is built on the commercialization of its advanced wound care and orthopedic products, which are sold under various brand names. TRX also benefits from partnerships with healthcare institutions and distributors that help expand its market reach. Additionally, the company may engage in collaborations or licensing agreements that provide upfront payments and royalties, further contributing to its earnings. The growth of its revenue is influenced by the increasing demand for regenerative medicine solutions and advancements in surgical techniques.

Tissue Regenix Earnings Call Summary

Earnings Call Date:Sep 30, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Jun 04, 2026
Earnings Call Sentiment Negative
The earnings call highlighted several positive developments, such as growth in specific product lines, new patents, and certifications. However, these were overshadowed by significant revenue declines, issues with regulatory approvals, and financial challenges. While there are strategic efforts underway to address these issues, the current financial and operational setbacks present substantial challenges.
Q2-2025 Updates
Positive Updates
Growth in dCELL Business
Despite challenges, the dCELL business grew by 10% year-over-year in H1 2025.
EU Patent and MDR Certification
Received an EU patent for the dCELL process and MDR certification, securing IP protection and compliance with new medical device regulations.
Increase in Demineralized Bone Matrix Orders
Orders for demineralized bone matrix products increased by 4% in H1 2025.
Publication of OrthoPure XT Clinical Results
The 5-year clinical results of OrthoPure XT were published in the Journal of Experimental Orthopaedics.
Negative Updates
Revenue Decline
Group revenues were down 6% in H1 2025 compared to H1 2024, with the BioRinse business down 7% and dCELL business down 4%.
Decrease in Gross Profit
Gross profit decreased due to lower yields from donor tissue and increased inventory costs.
Impact of CFG Delays
Delays in Certificates of Foreign Government impacted regulatory approvals, leading to a 45% decrease in the RDT business.
Decline in Strategic Partner Orders
Orders from a specific strategic partner decreased by 37% in H1 2025.
Increased Financial Strain
Decreased revenues and gross profit led to reduced EBITDA and increased reliance on revolving credit.
Company Guidance
During the investor presentation call for Tissue Regenix Group plc, the management team, including Executive Chairman Jay LeCoque, Chief Executive Officer Daniel Lee, and Interim Chief Financial Officer Brandon Largent, provided an overview of the company's financial performance and strategic initiatives. The company reported a 6% decline in group revenues for the first half of 2025 compared to the previous year, with the U.S.-based BioRinse business down 7% and the dCELL business down 4%. Despite these downturns, orders for demineralized bone matrix products increased by 4%, and the dCELL direct business grew by 10%. Gross profit decreased due to lower production yields and increased inventory costs, while adjusted EBITDA also fell year-over-year. The team highlighted significant advancements, such as receiving an EU patent for the dCELL process and MDR certification for the OrthoPure XT product. They also addressed issues related to delays in obtaining Certificates of Foreign Governments from the FDA, impacting the release donor tissue business, which saw a 45% decrease. The management team emphasized their commitment to strengthening the company's commercial approach, reviewing cost structures, and expanding geographically, despite current regulatory headwinds, to ensure sustainable long-term growth.

Tissue Regenix Financial Statement Overview

Summary
Tissue Regenix shows signs of operational improvement with better gross margins and reduced operating losses. However, the path to profitability remains challenging with continued net losses and negative cash flows. While the equity position provides some financial stability, increased leverage and reliance on external funding could pose risks.
Income Statement
62
Positive
The company has shown improvement in its gross profit margin, increasing from previous years, indicating better cost management. However, the net profit margin remains negative, reflecting ongoing challenges in achieving profitability. Revenue growth has been inconsistent, with fluctuations observed over the years. While the EBIT and EBITDA margins have improved, they remain low, highlighting the need for further operational efficiencies.
Balance Sheet
68
Positive
The company maintains a strong equity base, with a healthy equity ratio, suggesting financial stability. However, the debt-to-equity ratio has increased, indicating higher leverage, which could pose risks if not managed carefully. Return on equity remains negative due to net losses, underscoring the need for improved profitability to enhance shareholder value.
Cash Flow
55
Neutral
Cash flow from operations has been negative, impacting the company's ability to internally fund its activities. The free cash flow remains negative, highlighting potential liquidity constraints. The company has relied on financing activities to support its cash position, which could be unsustainable in the long term if operating cash flows do not improve.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue13.80M28.65M29.49M24.48M19.75M12.83M
Gross Profit5.77M13.62M14.04M9.14M5.63M5.13M
EBITDA5.00K1.36M446.00K-1.04M-3.04M-9.03M
Net Income-934.00K-713.00K-1.71M-2.69M-4.79M-9.71M
Balance Sheet
Total Assets47.19M45.35M43.24M38.27M34.13M36.73M
Cash, Cash Equivalents and Short-Term Investments1.07M1.87M4.65M4.95M5.69M9.55M
Total Debt11.00M10.46M9.39M9.61M7.95M7.22M
Total Liabilities18.56M16.29M13.89M13.00M9.47M8.88M
Stockholders Equity29.36M29.82M30.15M31.25M25.35M28.46M
Cash Flow
Free Cash Flow-252.00K-5.70M177.00K-2.29M-3.93M-6.84M
Operating Cash Flow-202.00K-1.64M1.04M-1.41M-2.45M-5.47M
Investing Cash Flow-592.00K-4.06M-837.00K-1.08M-2.04M-1.86M
Financing Cash Flow-2.00K3.28M-1.51M910.00K-192.00K17.68M

Tissue Regenix Technical Analysis

Technical Analysis Sentiment
Negative
Last Price7.25
Price Trends
50DMA
7.55
Negative
100DMA
17.44
Negative
200DMA
25.74
Negative
Market Momentum
MACD
-0.34
Negative
RSI
12.03
Positive
STOCH
50.00
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GB:TRX, the sentiment is Negative. The current price of 7.25 is above the 20-day moving average (MA) of 7.25, below the 50-day MA of 7.55, and below the 200-day MA of 25.74, indicating a neutral trend. The MACD of -0.34 indicates Negative momentum. The RSI at 12.03 is Positive, neither overbought nor oversold. The STOCH value of 50.00 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for GB:TRX.

Tissue Regenix Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
56
Neutral
£27.94M-3.35-204.29%3.31%21.91%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
49
Neutral
£5.16M-4.90-5.41%-20.31%-19.35%
47
Neutral
£20.71M-6.25-202.14%23.76%
40
Underperform
£6.26M-0.11-333.59%45.22%55.71%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GB:TRX
Tissue Regenix
7.25
-50.75
-87.50%
GB:FUM
Futura Medical
1.16
-32.02
-96.50%
GB:IMM
ImmuPharma
6.20
5.05
439.13%
GB:OBD
Oxford BioDynamics
0.26
-0.95
-78.75%
GB:SAR
Sareum Holdings
13.00
-13.50
-50.94%
GB:AREC
Arecor Therapeutics PLC
80.00
11.50
16.79%

Tissue Regenix Corporate Events

Delistings and Listing ChangesPrivate Placements and FinancingBusiness Operations and Strategy
Tissue Regenix Secures £17.5M Funding and Plans AIM Delisting
Neutral
Dec 4, 2025

Tissue Regenix has announced a conditional fundraising of £17.5 million through Secured Convertible Loan Notes to Harwood Private Equity, an existing substantial shareholder. Alongside this, the company plans to cancel its AIM listing due to disproportionate costs and limited benefits, re-register as a private entity, and adopt new articles of association. This strategic move is intended to streamline operations and provide a more cost-effective capital access, impacting its market presence and shareholder engagement.

Private Placements and FinancingBusiness Operations and Strategy
Tissue Regenix Secures Emergency Funding Amidst Strategic Financial Planning
Negative
Dec 1, 2025

Tissue Regenix has secured an emergency overdraft of $500K to maintain operations and is in discussions with shareholders regarding further funding needs. The company plans to raise funds through a convertible loan note, pending shareholder approval, to support revenue growth and operational stability.

Private Placements and FinancingFinancial Disclosures
Tissue Regenix Faces Urgent Capital Raise Amid Financial Challenges
Negative
Nov 7, 2025

Tissue Regenix has announced an urgent need to raise capital due to a substantial backlog of creditors and limited cash reserves, following a restatement of revenue numbers for the financial year 2024. The company is in discussions with major shareholders to raise approximately £5 million through a convertible loan note, which is crucial for its continued operation and subject to shareholder approval.

Delistings and Listing ChangesFinancial Disclosures
Tissue Regenix Suspends Trading to Address Financial Review
Negative
Oct 22, 2025

Tissue Regenix has temporarily suspended trading of its shares on AIM to allow its new leadership team to review and address financial discrepancies related to the restatement of revenue numbers for the fiscal year 2024. The company is implementing strict financial controls and aims to reduce costs by over $2 million, with a commitment to business recovery and sustainable growth.

Executive/Board ChangesBusiness Operations and Strategy
Tissue Regenix Strengthens Leadership with New Board Appointment
Positive
Oct 17, 2025

Tissue Regenix has announced that Kirsten Lund, the Chief Financial Officer, has joined the company’s board with immediate effect. This move is part of the company’s strategic efforts to strengthen its leadership team, potentially enhancing its operational efficiency and market positioning in the regenerative medical devices industry.

Executive/Board ChangesBusiness Operations and StrategyFinancial Disclosures
Tissue Regenix Announces Financial Restatement and Leadership Changes
Negative
Oct 16, 2025

Tissue Regenix announced significant financial and organizational changes, including a restatement of FY24 adjusted EBITDA from a profit to a loss and the departure of CEO Daniel Lee. The company has appointed Jay LeCoque as Acting CEO and Executive Chairman and reappointed Kirsten Lund as CFO to implement strict financial controls and a cost reduction initiative. These changes aim to improve financial performance and expand the company’s market presence, with a focus on sustainable, long-term growth.

Business Operations and StrategyFinancial DisclosuresRegulatory Filings and Compliance
Tissue Regenix Reports Revenue Decline Amid Regulatory Challenges
Negative
Sep 30, 2025

Tissue Regenix Group PLC reported a 6% decrease in revenue for the first half of 2025, primarily due to commercial, regulatory, and reimbursement challenges. Despite a downturn in trading and a reduced cash position, the company remains optimistic about its long-term growth prospects, supported by recent certifications and patents, as well as an expanded distribution network. Management changes and strategic focus on sustainable revenue opportunities aim to enhance shareholder value.

Executive/Board ChangesBusiness Operations and StrategyFinancial DisclosuresRegulatory Filings and Compliance
Tissue Regenix Faces Revenue Decline Amid Regulatory Challenges
Neutral
Sep 30, 2025

Tissue Regenix Group reported a 6% revenue decline for the first half of 2025, attributed to commercial, regulatory, and reimbursement challenges. The company’s BioRinse® and dCELL® product lines faced revenue decreases, while the gross profit margin fell to 42% due to lower production yields. Despite these setbacks, the company received CE certification for OrthoPure® XT and a European patent for dCELL® technology, and expanded its dCELL distribution network. Management changes were also announced, with new appointments and resignations. The company remains optimistic about future growth and aims to improve trading and cash flow in the long term.

Financial Disclosures
Tissue Regenix to Release Interim Results with Investor Presentation
Neutral
Sep 17, 2025

Tissue Regenix announced that it will release its interim results on 30 September 2025, with a live online presentation hosted by the CEO and Executive Chairman. This event is open to current and potential shareholders, indicating the company’s commitment to transparency and engagement with its stakeholders.

Executive/Board ChangesBusiness Operations and Strategy
Tissue Regenix Appoints Jay LeCoque as Executive Chairman Amid Board Reshuffle
Positive
Sep 8, 2025

Tissue Regenix has announced significant changes to its Board of Directors, with Jay LeCoque appointed as the new Executive Chairman. LeCoque brings over 25 years of experience in senior management within the life sciences sector, which is expected to strengthen the company’s growth and earnings. The resignations of Jonathan Glenn and Trevor Phillips from the Board were also announced, with the company expressing gratitude for their contributions. The appointment of LeCoque is seen as a strategic move to enhance the company’s position in the global healthcare and clinical life sciences market.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 07, 2025