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Physiomics PLC (GB:PYC)
LSE:PYC
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Physiomics (PYC) AI Stock Analysis

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GB

Physiomics

(LSE:PYC)

Rating:38Underperform
Price Target:
Physiomics' stock score is primarily impacted by significant financial instability, including declining revenues and negative profit margins. Technical indicators reinforce a bearish outlook. While recent corporate events suggest potential growth pathways, current valuation issues and financial challenges remain significant obstacles.

Physiomics (PYC) vs. iShares MSCI United Kingdom ETF (EWC)

Physiomics Business Overview & Revenue Model

Company DescriptionPhysiomics (PYC) is a healthcare and technology company specializing in the application of computational systems biology to improve drug development processes. It operates primarily in the biotechnology and pharmaceutical sectors, offering cutting-edge modeling and simulation services to optimize clinical trial designs and enhance drug development efficiency. Core services include Virtual Tumor technology and other predictive modeling tools that support decision-making in oncology drug development.
How the Company Makes MoneyPhysiomics makes money through service contracts with pharmaceutical and biotechnology companies, providing them with advanced modeling and simulation services to enhance their drug development processes. The company's key revenue streams are consultancy fees for their predictive modeling services, particularly in oncology, and licensing fees for their proprietary Virtual Tumor technology. Significant partnerships with leading pharmaceutical companies, which leverage Physiomics' expertise to accelerate and de-risk their drug development pipelines, contribute substantially to the company's earnings.

Physiomics Financial Statement Overview

Summary
Physiomics faces significant financial challenges with declining revenues, negative profit margins, and deteriorating cash flows. Despite being debt-free, the reduction in equity and persistent losses highlight the need for strategic improvements.
Income Statement
28
Negative
Physiomics has faced declining revenue over the years, with a negative revenue growth rate from 2023 to 2024. The company has consistently reported negative gross profit and net income, leading to unfavorable gross and net profit margins. The persistent negative EBIT and EBITDA margins further indicate operational challenges and inefficiencies.
Balance Sheet
45
Neutral
The company has managed to maintain a debt-free status, which is a positive aspect. However, the significant decline in stockholders' equity from 2023 to 2024 raises concerns about financial stability. The equity ratio has also decreased, reflecting a reduced ability to cover liabilities with equity.
Cash Flow
32
Negative
Physiomics has experienced deteriorating operating cash flow, with negative free cash flow reported consistently. The free cash flow growth rate is negative, and the operating cash flow to net income ratio is unfavorable, highlighting cash management issues.
BreakdownTTMJun 2024Jun 2023Jun 2022Jun 2021Jun 2020
Income Statement
Total Revenue517.56K543.25K597.35K830.27K702.31K799.05K
Gross Profit-688.12K-677.43K-581.62K-429.01K-365.79K-177.15K
EBITDA-674.37K-659.80K-561.57K-347.84K-324.52K-124.71K
Net Income-634.35K-609.35K-477.26K-253.14K-215.83K-64.42K
Balance Sheet
Total Assets1.41M422.60K674.39K1.12M1.32M1.45M
Cash, Cash Equivalents and Short-Term Investments1.15M191.07K416.59K687.67K1.04M1.05M
Total Debt0.000.000.000.000.000.00
Total Liabilities122.00K140.08K142.67K140.61K157.57K131.52K
Stockholders Equity1.29M282.53K531.72K974.81K1.17M1.31M
Cash Flow
Free Cash Flow-497.44K-565.44K-271.50K-358.62K-48.65K-120.78K
Operating Cash Flow-480.13K-548.13K-264.86K-349.25K-32.50K-115.69K
Investing Cash Flow-16.21K-15.21K-6.22K-9.37K-16.15K-5.09K
Financing Cash Flow362.83K337.83K0.002.85K44.24K763.28K

Physiomics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price0.48
Price Trends
50DMA
0.45
Positive
100DMA
0.44
Positive
200DMA
0.60
Negative
Market Momentum
MACD
<0.01
Positive
RSI
55.34
Neutral
STOCH
56.28
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GB:PYC, the sentiment is Positive. The current price of 0.48 is above the 20-day moving average (MA) of 0.47, above the 50-day MA of 0.45, and below the 200-day MA of 0.60, indicating a neutral trend. The MACD of <0.01 indicates Positive momentum. The RSI at 55.34 is Neutral, neither overbought nor oversold. The STOCH value of 56.28 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for GB:PYC.

Physiomics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (59)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
59
Neutral
HK$15.54B5.54-7.44%4.07%11.55%-28.15%
GBOXB
58
Neutral
£373.60M-66.23%43.84%74.88%
GBSAR
47
Neutral
£25.54M-87.30%71.17%
46
Neutral
£106.27M167.16%-100.00%-23.91%
42
Neutral
£123.77M-73.02%
GBPYC
38
Underperform
£1.44M-116.39%-21.33%-2.50%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GB:PYC
Physiomics
0.48
-0.20
-29.41%
GB:OXB
Oxford BioMedica
352.00
12.00
3.53%
GB:SCLP
Scancell Holdings
10.25
-1.15
-10.09%
GB:SAR
Sareum Holdings
19.00
-16.50
-46.48%
GB:AVCT
Avacta Group plc
32.00
-40.60
-55.92%

Physiomics Corporate Events

Product-Related AnnouncementsBusiness Operations and Strategy
Physiomics Secures New UK Contract for Antibody Therapy Development
Positive
Apr 17, 2025

Physiomics plc has secured a new contract with a UK client to apply its modelling and simulation techniques in the development of a bifunctional antibody therapy targeting multiple solid tumor indications. This project, valued at £47,600, will utilize pharmacokinetic modelling to predict human PK and support the client’s first-in-human study. The contract signifies Physiomics’ progress in expanding its client base and enhancing its role in developing oncology therapies.

Spark’s Take on GB:PYC Stock

According to Spark, TipRanks’ AI Analyst, GB:PYC is a Underperform.

Physiomics faces substantial financial and technical challenges, reflected in declining revenues and bearish technical indicators. Recent corporate events provide some optimism for future growth, but current valuation issues and financial instability weigh heavily on its stock score.

To see Spark’s full report on GB:PYC stock, click here.

Product-Related AnnouncementsBusiness Operations and Strategy
Physiomics Collaborates with Ankyra Therapeutics on IL-12 Drug Model Publication
Positive
Apr 16, 2025

Physiomics plc has announced the publication of a peer-reviewed article in collaboration with Ankyra Therapeutics, detailing a pharmacokinetic and pharmacodynamic model for an interleukin-12 anchored-drug conjugate aimed at treating solid tumors. This publication highlights the growing importance of mathematical modelling in drug development, showcasing Physiomics’ capability to support successful drug development programs and its strong positioning in the market amid increasing regulatory pressures.

Spark’s Take on GB:PYC Stock

According to Spark, TipRanks’ AI Analyst, GB:PYC is a Underperform.

Physiomics faces substantial financial and technical challenges, reflected in declining revenues and bearish technical indicators. Recent corporate events provide some optimism for future growth, but current valuation issues and financial instability weigh heavily on its stock score.

To see Spark’s full report on GB:PYC stock, click here.

Business Operations and Strategy
Physiomics Secures New Contract with Numab Therapeutics for Cancer Treatment Development
Positive
Apr 15, 2025

Physiomics plc has secured a new contract with Numab Therapeutics AG to apply modelling and simulation techniques in the pre-clinical development of a multi-specific antibody aimed at activating anti-tumor immune responses for cancer treatment. This collaboration underscores Physiomics’ role as a trusted partner in drug development, enhancing its industry positioning and reinforcing its long-term relationship with Numab Therapeutics.

Spark’s Take on GB:PYC Stock

According to Spark, TipRanks’ AI Analyst, GB:PYC is a Underperform.

Physiomics faces significant financial and technical challenges, with declining revenues and bearish technical signals. While recent corporate events indicate potential future growth, current valuation concerns and financial instability weigh heavily on its stock score.

To see Spark’s full report on GB:PYC stock, click here.

Business Operations and Strategy
Physiomics Secures New Contract in ADC Oncology Sector
Positive
Mar 17, 2025

Physiomics plc has secured a new contract with a UK-based biotech company focused on antibody drug conjugates (ADCs) for treating difficult cancers. This project, valued at £102,000, involves developing a Pharmacokinetic (PK) Pharmacodynamic (PD) model to optimize dosing for the client’s upcoming First-in-Human trial, running from April to August 2025. The contract reflects Physiomics’ strategy to diversify its client base and expand into new therapeutic areas, enhancing its industry positioning in the oncology treatment sector.

Business Operations and StrategyFinancial Disclosures
Physiomics Updates Stakeholders with Interim Results Presentation
Neutral
Mar 13, 2025

Physiomics plc has updated its website with a recent presentation and Q&A session from its Interim Results meeting, accessible via their website. This update aims to provide stakeholders with insights into the company’s current operations and strategic direction, potentially impacting its market positioning and stakeholder engagement.

Private Placements and FinancingBusiness Operations and StrategyFinancial Disclosures
Physiomics Reports Interim Financial Results and Strategic Growth Initiatives
Neutral
Mar 6, 2025

Physiomics plc reported interim financial results for the six-month period ending December 31, 2024, showing a slight decrease in revenue and an increase in operating loss compared to the previous year. Despite these financial challenges, the company has established a strong pipeline with new contracts and expanded its service offerings, including the launch of a Biostatistics service line and the development of Personalized Medicine Dosing Software. The company completed a successful fundraising effort, enhancing its cash position, and is on track to meet market expectations for the year, driven by a robust second half and strategic growth initiatives.

Business Operations and StrategyFinancial Disclosures
Physiomics Announces Interim Results and Investor Presentation
Positive
Feb 28, 2025

Physiomics plc announced it will release its interim results on March 6, 2025, followed by a live investor presentation on March 10, 2025. This presentation, led by CEO Peter Sargent and Chairman Jim Millen, will be open to existing and potential shareholders, providing an opportunity to discuss the interim results and broader business aspects. This initiative reflects Physiomics’ commitment to transparency and engagement with its stakeholders, potentially enhancing its industry positioning and investor relations.

Other
Physiomics PLC Announces Change in Major Shareholder Holdings
Neutral
Feb 20, 2025

Physiomics PLC has announced a change in major holdings, indicating a shift in the company’s shareholder structure. Ryan Mancrief has sold his holdings at Barclays Investment Solutions Limited, now holding 14,234,711 shares in a nominee account at AJ Bell plc, which represents 4.6947% of the company’s issued share capital. This change reflects a decrease from a previous position of 8.5127% and may impact the company’s voting dynamics and influence among stakeholders.

Private Placements and FinancingBusiness Operations and Strategy
Physiomics Raises £500,000 to Fuel Growth and Expansion
Positive
Feb 17, 2025

Physiomics plc announced the successful completion of its WRAP Retail Offer, raising £70,000, which combined with a previous placing, totals £500,000 in gross proceeds. The funds will support the company’s growth, including recruitment for its consulting services, investment in business development, and the expansion of its personalized medicine tools, signifying an effort to bolster its industry position and service offerings.

Private Placements and FinancingBusiness Operations and Strategy
Physiomics plc Launches Retail Offer to Raise £70,000
Positive
Feb 13, 2025

Physiomics plc has announced a retail offer via the Winterflood Retail Access Platform to raise up to £70,000 through the issuance of new ordinary shares. This offer is part of a broader strategy to raise approximately £500,000 through a separate placing of new shares. The funds raised will support the company’s ongoing operations and strategic initiatives. The offer is targeted exclusively at existing retail shareholders in the UK, emphasizing the company’s commitment to its retail shareholder base. The offer is not contingent upon the completion of the separate placing, ensuring flexibility in capital acquisition. This initiative reflects Physiomics’ strategic approach to strengthening its financial position and enhancing shareholder value.

Private Placements and FinancingBusiness Operations and Strategy
Physiomics plc Secures £430,000 to Boost Growth and Innovation
Positive
Feb 13, 2025

Physiomics plc has successfully completed a £430,000 placing to fund growth opportunities, issuing 86,000,000 new ordinary shares at a 37.5% discount. The company is also launching a retail offer to raise an additional £70,000. The funds will support the recruitment of technical staff, business development, and strategic growth in their consulting services. The company has made progress with new contract awards and publications, and aims to further its personalized medicine tools in collaboration with DoseMe. Recent achievements include contract wins and high-profile collaborations, positioning the company for continued growth and new business opportunities in the biotech and pharma sectors.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 30, 2025