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Physiomics PLC (GB:PYC)
LSE:PYC

Physiomics (PYC) AI Stock Analysis

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GB:PYC

Physiomics

(LSE:PYC)

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Neutral 48 (OpenAI - 5.2)
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Neutral 48 (OpenAI - 5.2)
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Neutral 48 (OpenAI - 5.2)
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Neutral 48 (OpenAI - 5.2)
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Neutral 48 (OpenAI - 5.2)
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Neutral 48 (OpenAI - 5.2)
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Neutral 48 (OpenAI - 5.2)
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Neutral 48 (OpenAI - 5.2)
Rating:48Neutral
Price Target:
0.42 p
▲(50.36% Upside)
Action:ReiteratedDate:03/12/26
The score is held back primarily by weak financial performance (ongoing losses and persistent cash burn), partially offset by a low-leverage balance sheet and some improvement in price trend. Valuation is constrained by negative earnings and lack of dividend support.
Positive Factors
Specialized computational drug-modelling services
Physiomics delivers specialized quantitative modelling and simulation services that translate biology and pharmacology into actionable decisions for pharma clients. That technical niche creates high switching costs, consultative relationships and structural demand from R&D budgets, supporting durable contract opportunities.
Strong recent revenue rebound
A material revenue rebound signals improving market adoption of services and stronger sales pipeline execution. If sustained, rising top-line can leverage fixed-cost modelling expertise to improve operating leverage, making future margin expansion and self-funding more achievable over several quarters.
Debt-free, low-leverage balance sheet
A debt-free capital structure provides financial flexibility and lower interest burden, reducing refinancing risk. For a services business with lumpy contracts, low leverage preserves optionality to raise equity or invest in growth without debt covenants, supporting resilience during uneven cash flows.
Negative Factors
Persistent losses and weak margins
Despite top-line recovery, the firm continues to report net losses and deeply negative margins. Ongoing unprofitability erodes shareholder value and indicates the business has not yet converted client demand into sustainable, profitable delivery; long-term viability depends on margin improvement.
Recurring cash burn
Consistent negative operating and free cash flow creates funding pressure and increases dependency on external capital. Persistent cash burn constrains reinvestment in sales and capability building, elevates dilution risk if equity raises are required, and weakens resilience to contract variability.
Small equity base and high negative ROE
A limited equity cushion combined with very negative ROE implies losses materially dilute shareholder capital. With modest assets and thin reserves, the company faces heightened refinancing and dilution risk if profitability and cash generation do not improve, restricting strategic flexibility.

Physiomics (PYC) vs. iShares MSCI United Kingdom ETF (EWC)

Physiomics Business Overview & Revenue Model

Company DescriptionPhysiomics Plc provides consulting services to pharmaceutical companies in the areas of outsourced quantitative pharmacology and computational biology in the United Kingdom, the United States, and the European Union. It offers modeling, simulation, and data analysis services covering various ranges of oncology research and development using its proprietary Virtual Tumour predictive software. The company also develops technology for use in the field of personalized medicine. Physiomics Plc was incorporated in 2001 and is based in Oxford, the United Kingdom.
How the Company Makes MoneyPhysiomics primarily makes money by selling contract-based services to external customers (typically pharmaceutical, biotechnology, and life-sciences organisations). Revenue is generated through paid engagements for modelling and simulation projects, which can include building and applying quantitative models to interpret preclinical/clinical data, assess drug behaviour and efficacy, and support R&D decisions. Depending on contract terms, income is commonly recognised as project fees and consultancy/service revenue (e.g., fixed-price deliverables and/or time-and-materials billing). If the company receives funding via collaborations, grants, or milestone-based arrangements, those proceeds would contribute to earnings when contractually due and recognisable; specific details of such partnerships, milestone structures, or recurring/licensing revenue are null if not publicly specified in the provided context.

Physiomics Financial Statement Overview

Summary
Revenue rebounded strongly in 2025, but the company remains loss-making with deeply negative margins and ongoing cash burn. A debt-free balance sheet helps, yet negative returns and recurring negative operating/free cash flow keep funding risk elevated.
Income Statement
24
Negative
Revenue rebounded strongly in 2025 (annual revenue up ~51% versus 2024), but profitability remains weak. The company is still loss-making with negative operating results and a net loss of ~£0.42M in 2025, and margins remain deeply negative. While losses improved versus 2024, the multi-year profile shows inconsistent revenue and a continued inability to convert sales into profits, which is a key overhang.
Balance Sheet
56
Neutral
The balance sheet looks comparatively cleaner than the income statement, with essentially no debt (2025 total debt at £0) and a meaningful equity base (~£0.69M) supporting ~£0.89M of assets. That said, returns remain negative (2025 return on equity around -60%), signaling ongoing value dilution risk if losses persist. Overall leverage is low, but the company still needs improved operating performance to protect the equity cushion.
Cash Flow
28
Negative
Cash burn remains significant: operating cash flow was about -£0.55M in 2025 and free cash flow about -£0.55M, indicating the business is not yet self-funding. Free cash flow modestly improved versus 2024 (less negative), but the multi-year pattern shows recurring negative operating and free cash flow, which keeps funding/refinancing risk elevated despite the low-debt capital structure.
BreakdownTTMJun 2024Jun 2023Jun 2022Jun 2021Jun 2020
Income Statement
Total Revenue953.00K784.00K543.25K597.35K830.27K702.31K
Gross Profit-543.08K-435.08K-677.43K-581.62K-429.01K-365.79K
EBITDA-553.33K-448.21K-659.80K-561.57K-347.84K-324.52K
Net Income-485.25K-415.25K-609.35K-477.26K-253.14K-215.83K
Balance Sheet
Total Assets558.00K892.03K422.60K674.39K1.12M1.32M
Cash, Cash Equivalents and Short-Term Investments257.00K461.24K191.07K416.59K687.67K1.04M
Total Debt0.000.003.83K7.35K0.000.00
Total Liabilities165.00K199.85K140.08K142.67K140.61K157.57K
Stockholders Equity393.00K692.17K282.53K531.72K974.81K1.17M
Cash Flow
Free Cash Flow-469.08K-550.08K-565.44K-271.50K-358.62K-48.65K
Operating Cash Flow-464.14K-546.14K-548.13K-264.86K-349.25K-32.50K
Investing Cash Flow-4.41K-3.41K-15.21K-6.22K-9.37K-16.15K
Financing Cash Flow456.73K819.73K337.83K0.002.85K44.24K

Physiomics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.28
Price Trends
50DMA
0.43
Negative
100DMA
0.39
Positive
200DMA
0.42
Negative
Market Momentum
MACD
>-0.01
Positive
RSI
43.34
Neutral
STOCH
46.00
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GB:PYC, the sentiment is Negative. The current price of 0.28 is below the 20-day moving average (MA) of 0.48, below the 50-day MA of 0.43, and below the 200-day MA of 0.42, indicating a bearish trend. The MACD of >-0.01 indicates Positive momentum. The RSI at 43.34 is Neutral, neither overbought nor oversold. The STOCH value of 46.00 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for GB:PYC.

Physiomics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
51
Neutral
£7.23M-7.18-15.57%13.32%55.07%
49
Neutral
£4.41M-0.88-53.79%85.56%
48
Neutral
£1.29M-0.72-89.43%44.32%60.00%
45
Neutral
£10.51M-0.25-316.67%72.17%79.03%
43
Neutral
£6.56M-2.61-2.42%
41
Neutral
£2.23M418.49%27.86%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GB:PYC
Physiomics
0.43
-0.02
-3.41%
GB:TCF
Evgen Pharma
0.21
-0.02
-6.82%
GB:IXI
IXICO plc
7.80
-1.70
-17.89%
GB:OPTI
OptiBiotix Health
6.35
-13.15
-67.44%
GB:OBD
Oxford BioDynamics
0.25
-0.24
-48.96%
GB:VAL
ValiRx plc
0.30
-0.30
-50.00%

Physiomics Corporate Events

Business Operations and StrategyPrivate Placements and Financing
Physiomics Raises £600,000 Via Retail Offer and Placing to Support Growth
Positive
Mar 18, 2026

Physiomics plc, a UK AIM-listed specialist in modelling, simulation and data-driven decision support for drug development and personalised medicine, provides computational tools and bespoke models that help streamline discovery, pre-clinical and clinical programmes for leading biotech and pharma companies. Its Virtual Tumour platform and wider analytics capabilities underpin a commercial track record across more than 140 projects and over 125 targets and drugs.

The company has completed a WRAP Retail Offer raising £110,000 through the issue of 27,500,000 new shares at £0.004, alongside a previously announced placing of £490,000, bringing total gross proceeds of the fundraise to £600,000, subject only to admission to AIM. Following expected admission of the new shares on 20 March 2026, Physiomics’ enlarged issued share capital will rise to 453,208,718 ordinary shares, increasing its free float and providing additional capital to support operations and growth initiatives while altering voting rights calculations for existing shareholders.

The most recent analyst rating on (GB:PYC) stock is a Sell with a £0.40 price target. To see the full list of analyst forecasts on Physiomics stock, see the GB:PYC Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
Physiomics launches revised WRAP retail offer alongside £490,000 placing
Neutral
Mar 17, 2026

Physiomics plc has launched a revised retail equity offer via Winterflood’s Retail Access Platform to raise up to £110,000 by issuing as many as 27.5 million new shares at £0.004, matching the price of a concurrent £490,000 institutional placing. The fundraising, which follows the cancellation of a previous placing and retail offer, is aimed at giving existing UK retail shareholders the chance to participate on the same terms as institutional investors, with the new shares expected to be admitted to AIM around 20 March and ranking pari passu with existing stock.

Both the WRAP Retail Offer and the placing are conditional on admission of the new shares to trading on AIM, though the placing will proceed independently if the retail tranche does not complete. The move underlines Physiomics’ effort to diversify and deepen its investor base while securing fresh capital, but it also highlights the risks borne by small-cap investors, with the company stressing that shares are high risk, capital is at risk, and no prospectus will be published under UK public offer exemptions.

The most recent analyst rating on (GB:PYC) stock is a Sell with a £0.44 price target. To see the full list of analyst forecasts on Physiomics stock, see the GB:PYC Stock Forecast page.

Business Operations and StrategyFinancial DisclosuresPrivate Placements and Financing
Physiomics Raises £490,000 in Revised Placing and Launches Retail Offer to Fund Growth
Positive
Mar 17, 2026

Physiomics has raised £490,000 through a discounted placing of 122.5 million new shares at £0.004 each and plans to launch a WRAP retail offer of up to a further £110,000 for existing shareholders on the same terms. The revised fundraising replaces an earlier cancelled placing, removes the need for a previously called general meeting and is intended to support business development, capability expansion, personalised dosing software and exploration of strategic options as the company targets another record year of income after delivering 46% revenue growth in its last financial year.

Management says long-term shareholders have backed the business at a higher price than the scrapped March offer, signalling confidence in its growth trajectory and market expectations for FY26. The fresh capital will fund expansion of consulting services, further integration of its personalised dosing tools and corporate initiatives aimed at accelerating growth in modelling and biometrics services, potentially strengthening Physiomics’ competitive position and diversifying its customer base in the pharmaceutical services market.

The most recent analyst rating on (GB:PYC) stock is a Sell with a £0.44 price target. To see the full list of analyst forecasts on Physiomics stock, see the GB:PYC Stock Forecast page.

Business Operations and StrategyExecutive/Board ChangesShareholder Meetings
Physiomics Faces Shareholder Push for Full Board Overhaul
Negative
Mar 16, 2026

Physiomics plc has received a shareholder requisition to convene a general meeting seeking to overhaul its board, led by investor Michael Whitlow, who holds about 13.68% of the company’s share capital. The proposed resolutions would appoint four new directors and remove the existing four, amounting to a full board replacement if all motions pass.

The current board is taking legal advice to verify that the request complies with UK company law and, if valid, must call the meeting by early April with the vote to follow within 28 days of the notice. Directors, who had been in dialogue with Whitlow, publicly argue that a wholesale board change would be highly detrimental to the company and its shareholders, signalling a potentially contentious governance showdown that could reshape leadership and strategic direction.

The most recent analyst rating on (GB:PYC) stock is a Sell with a £0.48 price target. To see the full list of analyst forecasts on Physiomics stock, see the GB:PYC Stock Forecast page.

Private Placements and FinancingShareholder Meetings
Physiomics Raises £673k in Oversubscribed Retail and Placing Fundraise
Positive
Mar 13, 2026

Physiomics plc has completed an oversubscribed WRAP Retail Offer, raising gross proceeds of £223,279.48 through the issue of 74,426,493 new ordinary shares at the same price as a previously announced placing. Together, the retail offer and placing constitute a conditional fundraise of £673,279.36 via 224,426,453 new shares, subject to shareholder approvals at a general meeting and admission of the new shares to trading on AIM.

The company has set an expected timetable, with the general meeting scheduled for 7 April 2026 and admission of the new ordinary shares to AIM targeted for 8 April 2026. On admission, the new shares from both the placing and WRAP Retail Offer will rank pari passu with existing ordinary shares, meaning existing and new investors will hold the same class of equity once the fundraise completes.

The most recent analyst rating on (GB:PYC) stock is a Sell with a £0.48 price target. To see the full list of analyst forecasts on Physiomics stock, see the GB:PYC Stock Forecast page.

Private Placements and FinancingShareholder Meetings
Physiomics Opens Retail Share Offer Alongside Discounted Placing
Neutral
Mar 10, 2026

Physiomics plc has launched a Winterflood Retail Access Platform offer to raise up to £49,999.98 by issuing up to 16,666,660 new ordinary shares at £0.003 each, matching the price of a concurrent institutional placing of approximately £499,999.86. The fundraising, which is subject to shareholder approval at a 7 April 2026 general meeting and admission of the new shares to AIM around 8 April, is structured to give existing UK retail shareholders the chance to participate on the same terms as placing investors, potentially broadening the shareholder base while diluting existing holdings.

The WRAP Retail Offer is open only to existing UK shareholders via participating intermediaries, with a minimum subscription of £100 and the company retaining discretion over scaling back or rejecting applications. New shares issued under the offer will rank pari passu with existing stock, and the structure utilises UK prospectus exemptions, indicating a relatively small but strategically inclusive capital raise intended to support the same objectives as the larger placing without the cost and delay of a full prospectus.

The most recent analyst rating on (GB:PYC) stock is a Hold with a £0.44 price target. To see the full list of analyst forecasts on Physiomics stock, see the GB:PYC Stock Forecast page.

Business Operations and StrategyExecutive/Board ChangesFinancial Disclosures
Physiomics posts record half-year income as new Biometrics arm accelerates growth
Positive
Feb 16, 2026

Physiomics reported record first-half total income of £528,000 for the six months to 31 December 2025, up 51% year-on-year and its highest half-year income since inception, driven by expanded Modelling and Simulation work and a new Biometrics service line. Revenue rose to £498,000 but operating losses widened to £327,000 due to hiring and temporary reliance on external contractors, while cash stood at £257,000 and shareholders’ funds at £393,000.

The company launched its Biometrics service line, hired a new Head of Biometrics and a senior quantitative pharmacology scientist, and secured 11 new contracts, including deals with longstanding client Numab Therapeutics and global health organisation GARDP. Management expects full-year 2026 income to meet market forecasts for a 27% increase versus 2025 and anticipates a 24% reduction in loss after tax, supported by better utilisation of internal staff, reduced use of external consultants, and a robust pipeline extending into 2027 including new international biopharma clients and data access for its personalised dosing software.

The most recent analyst rating on (GB:PYC) stock is a Hold with a £0.63 price target. To see the full list of analyst forecasts on Physiomics stock, see the GB:PYC Stock Forecast page.

Business Operations and Strategy
Physiomics wins South Korean oncology modelling contract
Positive
Feb 12, 2026

Physiomics plc has secured a new contract with a South Korean clinical-stage biopharmaceutical company developing next-generation antibody-drug conjugates and immuno-oncology therapies for cancer. The project, worth up to £66,600, will see Physiomics apply PK/PD modelling and simulation to guide dosing decisions for one of the client’s clinical assets, with work starting immediately and expected to complete within two months.

The mandate broadens Physiomics’ international client base and underscores its strategy of expanding into markets further afield, while highlighting the growing role of advanced quantitative modelling in de-risking oncology drug development. Management framed the win as validation of the company’s capabilities in providing data-driven insights that enhance decision-making for innovative cancer therapies at a critical clinical stage.

The most recent analyst rating on (GB:PYC) stock is a Hold with a £0.46 price target. To see the full list of analyst forecasts on Physiomics stock, see the GB:PYC Stock Forecast page.

Business Operations and Strategy
Physiomics Wins New Numab Therapeutics Contract to Model Key Immunology Asset
Positive
Jan 28, 2026

Physiomics plc has secured a new contract from long-standing client Numab Therapeutics AG to develop a pharmacokinetic-pharmacodynamic (PK/PD) model for a key asset in Numab’s immunology and inflammation pipeline, reinforcing its role as a specialist partner in quantitative drug development. The project, which is due to start immediately and conclude by the second quarter of 2026, will inform the target candidate profile at an early stage to support data-driven R&D decisions, deepening the companies’ collaboration and highlighting the growing reliance of next-generation antibody developers on advanced modelling to accelerate and de-risk pipeline progression.

The most recent analyst rating on (GB:PYC) stock is a Hold with a £0.27 price target. To see the full list of analyst forecasts on Physiomics stock, see the GB:PYC Stock Forecast page.

Business Operations and StrategyExecutive/Board Changes
Physiomics Grants Premium-Priced Options to Biometrics Head to Support Growth Strategy
Positive
Dec 23, 2025

Physiomics has granted a total of 4,548,132 share options under its existing option scheme, including a new award of 4,548,132 options to Head of Biometrics Jesse Thissen, structured across three tranches with exercise prices set at substantial premiums to the current share price and vesting between July 2026 and July 2028. The Board positions the grant as a key retention and incentive tool as the company scales its biometrics service line, which has already secured three contracts within six months of Thissen’s appointment, supporting its wider strategy to drive growth and move towards cash generation.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Mar 12, 2026