Strong Q4 and Full-Year Sales Growth
Total sales of $1.57 billion in Q4, up 11.6% year‑over‑year; full‑year 2025 sales growth of 10.7% — demonstrating broad-based demand and momentum entering 2026.
TAVR Performance and Clinical Momentum
TAVR Q4 global sales of $1.16 billion, up 10.6% year‑over‑year; overall procedural growth in the quarter remained in the high single digits. Strength supported by seven‑year PARTNER 3 and ten‑year PARTNER 2 durability data, Early TAVR evidence (including asymptomatic indication), strong SAPIEN 3 Ultra Resilia adoption, and supportive Europe guideline changes — all cited as durable growth catalysts.
TMTT Segment Surge
TMTT grew over 40% in Q4 to $156 million; full‑year TMTT sales exceeded $500 million. Growth driven by PASCAL and EVOQUE adoption, FDA approval and initial launch of SAPIEN M3, NextGen PASCAL rollout, and expected contribution toward a $2 billion TMTT revenue target by 2030.
Surgical Business Milestones
Surgical Q4 sales of $254 million, up 2% year‑over‑year; full‑year surgical sales grew 4.3% and exceeded $1 billion for the first time. Positive MOMENTYS one‑year data (100% freedom from SVD) and planned initial introduction of surgical LAAC later this year provide new product and clinical catalysts.
Profitability and Margin Discipline
Q4 adjusted gross profit margin of 78.3% (vs. 79% year‑ago) and Q4 adjusted operating profit margin of 23.7%; full‑year 2025 adjusted operating margin of 27%. Company expects full‑year 2026 adjusted gross margin to be ~78%–79% and forecasted ~150 basis points of constant‑currency operating margin expansion in 2026.
Strong Balance Sheet and Capital Return
Approximately $3 billion in cash and cash equivalents as of Dec 31, 2025; repurchased just under $900 million of stock in 2025 (including ~$40 million in Q4) and ~ $2 billion of share repurchase authorization remaining.
Confident 2026 Guidance and Near‑Term Outlook
Management expressed increased confidence in meeting 2026 sales growth guidance of 8%–10% and EPS guidance of $2.90–$3.05. Q1 2026 sales guidance of $1.55 billion–$1.63 billion and Q1 adjusted EPS guidance of $0.70–$0.76; FX expected to provide ~ $40 million upside to full‑year 2026 sales at current rates.
Patient Access & Clinical Engagement Initiatives
Increased investments in patient access initiatives, including partnership with the American Heart Association Heart Valve initiative, European guideline dissemination efforts, and field force reinforcement — aimed at driving earlier, guideline‑based treatment and expanding addressable market.