Differentiated Safety ProfileTegoprubart showed a favorable safety profile versus standard immunosuppression, with fewer rejection episodes, less new-onset diabetes, and no evidence of kidney, blood pressure, or neurological toxicity in treated patients.
Islet Transplant EfficacyTegoprubart produced rapid and sustained improvements in blood sugar control and led to insulin independence in investigator-led islet transplant patients, with no transplant rejection or new donor-specific immune responses reported.
Regulatory And Trial Advancement PotentialCompany engagement with the FDA to review islet transplant data and supportive biomarker results could enable agreement on a regulatory path and the design of a late-stage trial for tegoprubart.