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Precision Biosciences (DTIL)
:DTIL

Precision BioSciences (DTIL) AI Stock Analysis

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Precision BioSciences

(NASDAQ:DTIL)

Rating:41Neutral
Price Target:
$4.00
▼(-6.10%Downside)
The overall stock score is driven by financial performance and valuation concerns. The company struggles with negative earnings and cash flow, impacting its financial stability. Technical indicators point to bearish momentum, compounding the negative outlook. Despite positive corporate events, these do not currently offset the financial and technical challenges.
Positive Factors
Preclinical Data
PBGENE-DMD was found to have increased and durable therapeutic benefit as seen through 3 to 9 months post-treatment compared to diseased mice.
Regulatory Progress
The FDA has granted a Rare Pediatric Disease (RPD) Designation for PBGENE-DMD.
Strategic Opportunities
Precision's multi-exon excision strategy could apply to up to 60% of DMD cases, offering a broader treatment approach than current exon skipping drugs.
Negative Factors
Clinical Data Concerns
Investors' key holdup in the stock has been the lack of meaningful clinical data to validate the ARCUS gene editing technology.
Market Competition
A key concern for investors is the lack of meaningful clinical data to validate the ARCUS gene editing technology and its long-lasting clinical benefits with minimal safety concerns.
Safety Concerns
Future updates at higher doses with 2-3 administrations are expected to have a greater degree of toxicity.

Precision BioSciences (DTIL) vs. SPDR S&P 500 ETF (SPY)

Precision BioSciences Business Overview & Revenue Model

Company DescriptionPrecision BioSciences, Inc., a clinical stage gene editing company, develops in vivo gene editing and ex vivo allogeneic CAR T therapies in the United States. It offers ARCUS, a genome editing platform to cure genetic disorders. The company also provides Ex vivo Allogeneic CAR T Immunotherapy, a form of immunotherapy in which T cell, a specific type of immune cell is genetically engineered to recognize and kill cancer cells; PBCAR0191, which is in Phase 1/2a clinical trial in adult patients with R/R NHL or R/R B-cell precursor acute lymphoblastic leukemia, or B-ALL; PBCAR19B, an anti-CD19 CAR T candidate built on the stealth cell platform utilizing a single-step gene edit to minimize the risk of chromosome abnormalities; and PBCAR269A, an investigational allogeneic CAR T immunotherapy targeting BCMA for the treatment of R/R multiple myeloma. The company has development and commercial license agreement with Les Laboratoires Servier to develop allogeneic chimeric antigen receptor T cell therapies for antigen targets, hematological cancer targets beyond CD19, and solid tumor targets; Tiziana Life Sciences to evaluate foralumab, a fully human anti-CD3 monoclonal antibody as a lymphodepleting agent for the potential treatment of cancers; and iECURE, Inc. to develop ARCUS-based gene editing therapies. Precision BioSciences, Inc. was incorporated in 2006 and is headquartered in Durham, North Carolina.
How the Company Makes MoneyPrecision BioSciences generates revenue through the development and commercialization of its genome editing technologies. The company's primary revenue streams include licensing agreements and strategic partnerships with other biotechnology and pharmaceutical companies, which utilize the ARCUS platform for their own therapeutic and agricultural applications. Additionally, Precision BioSciences may earn revenue from research and development collaborations, government grants, and potential milestone payments based on the progress and success of its development programs. The company also has the potential to benefit from future product sales if its therapies receive regulatory approval and are brought to market.

Precision BioSciences Financial Statement Overview

Summary
Precision BioSciences faces significant financial challenges, particularly in profitability and cash flow. Despite a strong cash position, negative earnings, declining equity, and inconsistent revenue growth are major concerns.
Income Statement
45
Neutral
The company shows fluctuating revenue with recent declines, as seen in the TTM (Trailing-Twelve-Months) figures. Gross profit margin is solid, but negative EBIT and net income margins indicate operational and profitability challenges. Revenue growth has been inconsistent with a significant drop in the latest TTM period.
Balance Sheet
50
Neutral
The company maintains a strong cash position relative to debt, indicating low leverage. However, stockholders' equity has decreased over time, and the equity ratio reflects a relatively weak capital structure. Debt-to-equity ratio is manageable, but the decline in equity is concerning.
Cash Flow
40
Negative
Free cash flow remains negative, with little improvement over time. Operating cash flow is consistently negative, indicating challenges in core business profitability. The operating cash flow to net income ratio is unfavorable, reflecting cash generation issues.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue51.14M68.70M48.73M25.10M115.53M24.29M
Gross Profit51.14M68.70M40.47M16.09M115.53M24.29M
EBITDA-16.57M13.53M-32.04M-62.79M-20.27M-99.19M
Net Income-21.99M7.17M-61.32M-122.91M-30.92M-109.01M
Balance Sheet
Total Assets124.41M136.39M159.78M238.17M211.50M150.16M
Cash, Cash Equivalents and Short-Term Investments77.22M86.31M116.68M189.58M143.66M89.80M
Total Debt1.36M30.05M31.27M27.04M9.11M10.52M
Total Liabilities75.07M80.00M140.92M177.74M120.33M105.73M
Stockholders Equity49.34M56.39M18.86M60.43M91.17M44.42M
Cash Flow
Free Cash Flow-58.74M-58.70M-86.39M-49.07M-16.66M-92.42M
Operating Cash Flow-58.52M-58.45M-84.11M-45.75M-10.85M-87.39M
Investing Cash Flow-503.00K-215.00K5.83M-3.32M-5.80M-5.03M
Financing Cash Flow21.04M50.45M5.39M94.98M70.52M1.33M

Precision BioSciences Technical Analysis

Technical Analysis Sentiment
Negative
Last Price4.26
Price Trends
50DMA
4.95
Negative
100DMA
5.00
Negative
200DMA
5.98
Negative
Market Momentum
MACD
-0.21
Positive
RSI
41.74
Neutral
STOCH
23.43
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For DTIL, the sentiment is Negative. The current price of 4.26 is below the 20-day moving average (MA) of 4.72, below the 50-day MA of 4.95, and below the 200-day MA of 5.98, indicating a bearish trend. The MACD of -0.21 indicates Positive momentum. The RSI at 41.74 is Neutral, neither overbought nor oversold. The STOCH value of 23.43 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for DTIL.

Precision BioSciences Risk Analysis

Precision BioSciences disclosed 73 risk factors in its most recent earnings report. Precision BioSciences reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Precision BioSciences Peers Comparison

Overall Rating
UnderperformOutperform
Sector (64)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
68
Neutral
$390.71M5.00-58.97%23.81%146.45%
64
Neutral
€7.32B20.880.61%1.91%1.18%-29.88%
41
Neutral
$63.22M-30.49%-100.00%37.59%
41
Neutral
$48.12M2.40-50.81%-11.11%79.74%
36
Underperform
$40.45M-62.41%10.84%
27
Underperform
$50.20M-55.83%59.75%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
DTIL
Precision BioSciences
4.34
-4.86
-52.83%
CTMX
CytomX Therapeutics
2.50
1.21
93.80%
ACET
Adicet Bio
0.61
-0.46
-42.99%
IKNA
Ikena Oncology
1.33
-0.33
-19.88%
ACRV
Acrivon Therapeutics, Inc.
1.29
-5.78
-81.75%

Precision BioSciences Corporate Events

Executive/Board ChangesShareholder Meetings
Precision BioSciences Holds Annual Stockholder Meeting
Neutral
Jun 3, 2025

On May 28, 2025, Precision BioSciences, Inc. held its annual meeting of stockholders, where 71% of the common stock was represented. The meeting resulted in the election of Kevin J. Buehler and Shari Lisa Piré as Class III directors, and the approval of several proposals, including the ratification of Deloitte & Touche LLP as the independent accounting firm and an annual advisory vote on executive compensation. However, a proposal to amend the Certificate of Incorporation regarding officer exculpation did not pass as it failed to meet the required voting threshold.

The most recent analyst rating on (DTIL) stock is a Buy with a $60.00 price target. To see the full list of analyst forecasts on Precision BioSciences stock, see the DTIL Stock Forecast page.

Business Operations and StrategyFinancial Disclosures
Precision BioSciences Reports Q1 Results and Business Update
Positive
May 15, 2025

On May 15, 2025, Precision BioSciences reported its first quarter financial results and provided a business update, highlighting new clinical data for its ARCUS-based programs. The company announced progress in its ELIMINATE-B trial for PBGENE-HBV, a potential curative treatment for chronic Hepatitis B, which received Fast Track Designation from the FDA. Additionally, Precision is accelerating its PBGENE-DMD program for Duchenne’s Muscular Dystrophy, aiming to file an IND/CTA in 2025, with clinical data expected in 2026. The company plans to pause the development of PBGENE-3243 to focus resources on these programs.

The most recent analyst rating on (DTIL) stock is a Buy with a $60.00 price target. To see the full list of analyst forecasts on Precision BioSciences stock, see the DTIL Stock Forecast page.

Product-Related AnnouncementsBusiness Operations and Strategy
Precision BioSciences Accelerates PBGENE-DMD Program for DMD
Positive
May 14, 2025

On May 14, 2025, Precision BioSciences announced the acceleration of its PBGENE-DMD program, a first-in-class in vivo gene editing approach for Duchenne Muscular Dystrophy (DMD), highlighting preclinical evidence at the ASGCT Annual Meeting. The program aims to address the significant unmet need for DMD treatments by restoring the body’s production of functional dystrophin protein, potentially offering a durable intervention for most patients. Precision plans to submit an IND and/or CTA in 2025, with clinical data expected in 2026, while pausing development of PBGENE-3243 to focus on advancing PBGENE-DMD and PBGENE-HBV through Phase 1 clinical results.

The most recent analyst rating on (DTIL) stock is a Buy with a $60.00 price target. To see the full list of analyst forecasts on Precision BioSciences stock, see the DTIL Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jun 26, 2025