Precision BioSciences (DTIL) AI Stock Analysis

• Market Cap: $58.93M
• Dividend Yield: N/A
• Average Volume (3M): 129.80K
• Price to Earnings (P/E): 2.4
• Beta (1Y): 1.15
• Revenue Growth: -98.56%
• EPS Growth: -347.81%
• Country: US
• Employees: 108
• Sector: Healthcare
• Sector Strength: 49
• Industry: Biotechnology
• EPS (TTM): -2.13
• Shares Outstanding: 11,786,991
• 10 Day Avg. Volume: 69,586
• 30 Day Avg. Volume: 129,796
• PEG Ratio: N/A
• Price to Book (P/B): N/A
• Price to Sales (P/S): N/A
• P/FCF Ratio: N/A
• Enterprise Value/Market Cap: 0.23
• Enterprise Value/Revenue: 10.78
• Enterprise Value/Gross Profit: 24.07
• Enterprise Value/Ebitda: -0.18
• 1Y Price Target: $36.33
• Price Target Upside: 622.27% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 3

• Rating: 51 Neutral
• Price Target: $5.00 ▼(-0.60% Downside)

The overall stock score is primarily impacted by significant financial challenges, including revenue decline and profitability issues. However, the promising Phase 1 trial results for PBGENE-HBV provide a positive outlook for future growth. Technical indicators show moderate strength, but poor valuation due to negative earnings remains a concern.

Positive Factors

Financial Stability

Precision Biosciences has a cash runway into the second half of 2027, indicating financial stability and the ability to advance its programs.

Innovative Treatments

Precision's targeting of cccDNA is potentially curative for chronic hepatitis B, offering an innovative approach where current treatments only suppress the disease.

Regulatory Approvals

Precision was granted FDA rare pediatric disease and orphan drug designation for PBGENE-DMD for the treatment of DMD.

Negative Factors

Antigen Upregulation

There was a compensatory upregulation of antigens (HBsAg) in two patients, causing their levels to return to baseline.

Efficacy Concerns

Current dose levels in human trials are significantly lower than those that showed over 90% antigen reduction in animal studies, indicating a gap in efficacy.

Precision BioSciences Business Overview & Revenue Model

Company Description

Precision BioSciences, Inc., a clinical stage gene editing company, develops in vivo gene editing and ex vivo allogeneic CAR T therapies in the United States. It offers ARCUS, a genome editing platform to cure genetic disorders. The company also provides Ex vivo Allogeneic CAR T Immunotherapy, a form of immunotherapy in which T cell, a specific type of immune cell is genetically engineered to recognize and kill cancer cells; PBCAR0191, which is in Phase 1/2a clinical trial in adult patients with R/R NHL or R/R B-cell precursor acute lymphoblastic leukemia, or B-ALL; PBCAR19B, an anti-CD19 CAR T candidate built on the stealth cell platform utilizing a single-step gene edit to minimize the risk of chromosome abnormalities; and PBCAR269A, an investigational allogeneic CAR T immunotherapy targeting BCMA for the treatment of R/R multiple myeloma. The company has development and commercial license agreement with Les Laboratoires Servier to develop allogeneic chimeric antigen receptor T cell therapies for antigen targets, hematological cancer targets beyond CD19, and solid tumor targets; Tiziana Life Sciences to evaluate foralumab, a fully human anti-CD3 monoclonal antibody as a lymphodepleting agent for the potential treatment of cancers; and iECURE, Inc. to develop ARCUS-based gene editing therapies. Precision BioSciences, Inc. was incorporated in 2006 and is headquartered in Durham, North Carolina.

How the Company Makes Money

Precision BioSciences generates revenue through a combination of partnerships, collaborations, and licensing agreements. The company often enters into strategic alliances with pharmaceutical companies to co-develop therapies, which can provide upfront payments, research funding, and milestone payments as specific development goals are achieved. Additionally, Precision BioSciences may receive royalties on future product sales resulting from these collaborations. The company also pursues grant funding and may generate revenue from its proprietary technology through licensing deals, allowing others to utilize its ARCUS genome editing platform in their own research and development efforts.

Precision BioSciences Financial Statement Overview

Summary

Precision BioSciences faces significant financial challenges, particularly in profitability and cash flow. The company has a solid gross profit margin but struggles with negative earnings and cash flow generation. Despite a strong cash position, declining equity and inconsistent revenue growth pose risks. Overall, financial stability and growth trajectory are concerns that need addressing.

Income Statement

The company shows fluctuating revenue with recent declines, as seen in the TTM (Trailing-Twelve-Months) figures. Gross profit margin is solid, but negative EBIT and net income margins indicate operational and profitability challenges. Revenue growth has been inconsistent with a significant drop in the latest TTM period.

Balance Sheet

The company maintains a strong cash position relative to debt, indicating low leverage. However, stockholders' equity has decreased over time, and the equity ratio reflects a relatively weak capital structure. Debt-to-equity ratio is manageable, but the decline in equity is concerning.

Cash Flow

Free cash flow remains negative, with little improvement over time. Operating cash flow is consistently negative, indicating challenges in core business profitability. The operating cash flow to net income ratio is unfavorable, reflecting cash generation issues.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	1.26M	68.70M	48.73M	25.10M	115.53M	24.29M
Gross Profit	565.00K	68.70M	40.47M	16.09M	115.53M	24.29M
EBITDA	-73.73M	13.53M	-32.04M	-62.79M	-20.27M	-99.19M
Net Income	-78.25M	7.17M	-61.32M	-122.91M	-30.92M	-109.01M
Balance Sheet
Total Assets	108.93M	136.39M	159.78M	238.17M	211.50M	150.16M
Cash, Cash Equivalents and Short-Term Investments	62.24M	86.31M	116.68M	189.58M	143.66M	89.80M
Total Debt	29.45M	30.05M	31.27M	27.04M	9.11M	10.52M
Total Liabilities	74.87M	80.00M	140.92M	177.74M	120.33M	105.73M
Stockholders Equity	34.05M	56.39M	18.86M	60.43M	91.17M	44.42M
Cash Flow
Free Cash Flow	-64.12M	-58.70M	-86.39M	-49.07M	-16.66M	-92.42M
Operating Cash Flow	-63.92M	-58.45M	-84.11M	-45.75M	-10.85M	-87.39M
Investing Cash Flow	-487.00K	-215.00K	5.83M	-3.32M	-5.80M	-5.03M
Financing Cash Flow	25.64M	50.45M	5.39M	94.98M	70.52M	1.33M

Precision BioSciences Technical Analysis

• Technical Analysis Sentiment: Positive
• Last Price: 5.03
• 50DMA: Positive
• 100DMA: Positive
• 200DMA: Negative
• MACD: Negative
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For DTIL, the sentiment is Positive. The current price of 5.03 is above the 20-day moving average (MA) of 4.81, above the 50-day MA of 4.69, and below the 200-day MA of 5.09, indicating a neutral trend. The MACD of 0.09 indicates Negative momentum. The RSI at 56.24 is Neutral, neither overbought nor oversold. The STOCH value of 73.18 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for DTIL.

Precision BioSciences Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
CTMX	61 Neutral	$343.02M	3.71	108.21%	―	18.01%	306.76%
Sector *	51 Neutral	$7.91B	-0.36	-41.70%	2.23%	23.45%	-1.86%
DTIL	51 Neutral	$58.93M	2.40	-143.89%	―	-98.56%	-347.81%
BLUE	51 Neutral		―		―	127.51%	56.94%
IMA	41 Neutral	$149.39M	―	-23.76%	―	-100.00%	55.32%
ACRV	36 Underperform	$40.89M	―	-47.87%	―	―	18.86%
ACET	27 Underperform	$61.14M	―	-64.39%	―	―	48.45%

Precision BioSciences Corporate Events

Precision BioSciences Updates Executive Employment Agreements

On August 26, 2025, Precision BioSciences amended and restated employment agreements for its key executives to retain them and reflect updated compensation terms. These agreements include provisions for termination without cause and require funding of severance and expenses in an escrow account, with interest and unused funds benefiting the company.

Precision BioSciences Reports Promising Phase 1 Trial Results

On August 6, 2025, Precision BioSciences announced results from its Phase 1 ELIMINATE-B clinical trial for PBGENE-HBV, a treatment for hepatitis B. The trial’s Cohort 1, which involved three patients receiving low-dose PBGENE-HBV, showed promising safety and efficacy results, with no serious adverse events and significant reductions in hepatitis B surface antigen levels. Cohort 2 is underway, with one patient completing three doses and two others receiving one dose each, showing similar safety profiles. The favorable outcomes have led to the recommendation to initiate Cohort 3, with further updates expected later in 2025.

Precision BioSciences Holds Annual Stockholder Meeting

On May 28, 2025, Precision BioSciences, Inc. held its annual meeting of stockholders, where 71% of the common stock was represented. The meeting resulted in the election of Kevin J. Buehler and Shari Lisa Piré as Class III directors, and the approval of several proposals, including the ratification of Deloitte & Touche LLP as the independent accounting firm and an annual advisory vote on executive compensation. However, a proposal to amend the Certificate of Incorporation regarding officer exculpation did not pass as it failed to meet the required voting threshold.