Growth Portfolio Outperformance
Growth portfolio revenue increased 15% year-over-year in Q4 (to $7.4B) and 17% for the full year, representing ~60% of total Q4 revenue and nearly offsetting ~ $4B decline in the legacy portfolio for the year.
Multiple High-Performing Products
Opdualag, Breyanzi, and Camzyos each exceeded $1B in full-year sales; Reblozyl exceeded $2B. Notable Q4 product growth: Breyanzi +47% (Q4), Reblozyl +21% (Q4), Camzyos +57% (Q4), Opdivo +7% (Q4), Eliquis +6% (Q4).
Strong Commercial Momentum for New Launches
Early launches showed traction: Qvantik $133M in Q4 with positive practice feedback; CoBinfy $51M in Q4 with uptake surpassing schizophrenia comparators and >100k TRx since launch.
Robust Pipeline and Near-Term Catalysts
Data-rich 2026: top-line registrational data expected for ~6 potential new products this year and over 30 meaningful launch opportunities by 2030. Key milestones include Breyanzi expansion (FDA approval in marginal zone lymphoma), multiple pemigatinib registrational studies, Break Free SSC for Zolacel, and upcoming Nablometastat oral data.
2026 Financial Guidance and EPS Outlook
2026 revenue guidance of $46.0B–$47.5B and adjusted diluted EPS guidance of $6.05–$6.35, reflecting continued growth portfolio performance and planned legacy declines.
Progress on Cost Savings and Expense Management
Delivered approximately $1B of a $2B strategic productivity initiative in 2025 with the remaining ~$1B targeted across 2026–2027. Full-year operating expenses (ex-IPR&D) decreased to $16.6B, down $1.2B vs 2024; 2026 operating expense guidance ~ $16.3B.
Balance Sheet and Cash Flow Strength
Approximately $11B in cash and marketable securities as of 12/31/2025, completed targeted $10B debt paydown ahead of schedule, and generated ~$2B operating cash flow in Q4.
Commercial Positioning and Market Access Wins
Eliquis remains a growth driver with US market share ~75% in AFib and company guidance expecting Eliquis revenue growth of 10%–15% in 2026; Opdualag and Opdivo share gains in metastatic melanoma and first-line NSCLC respectively; Opdivo subQ (Qvantik/Opdivo SC) adoption tracking to conversion target of 30%–40% of IV business by 2028.