Optimistic Buy Rating for Corbus Pharmaceuticals: Promising Phase 1 Results for CRB-913 in Obesity TreatmentThis morning, Corbus (Nasdaq: CRBP) announced 1) an update from the Phase 1 SAD/MAD study tesng their CB1 receptor inverse agonist, called CRB-913, that is being developed for the treatment of obesity, and 2) iniaon of the placebo-controlled 12-week 1 trial tesng CRB-913 for n=240 obese, non-diabec paents. Stepping back for a moment, a key focus for investors (and ourselves) on Corbus' Phase 1 trial with CRB-913 is the safety and tolerability profile of the asset, with parcular interest in the neuropsychiatric AEs given historical concerns. Specifically, the first-generaon CB1R inverse agonist rimonabant was denied FDA approval due to suicidality concerns, while Novo Nordisk (NYSE: NVO) reported neuropsychiatric AEs with its second-generaon CB1R inverse agonist, monlunabant (our note on the monlunabant data HERE).