QUVIVIQ Sales More Than Doubled
QUVIVIQ product sales increased from ~CHF 60–61 million in 2024 to CHF 134 million in 2025 (≈+123%), driving net revenue to CHF 214 million and exceeding the upgraded 2025 guidance (guided CHF 130 million). Company guides QUVIVIQ sales of ~CHF 200 million for 2026 (≈+49% vs 2025).
Strong Regional EUCAN Growth
EUCAN sales rose from CHF 32 million to CHF 108 million in 2025 (≈+238%), cited as the main driver of the QUVIVIQ sales increase.
Marked Improvement in Operational Losses
Non‑GAAP operating loss improved from CHF -308 million in 2024 to CHF -100 million in 2025, a reduction in loss of CHF 208 million (≈67.5% improvement). U.S. GAAP EBIT loss narrowed to CHF -33 million.
Liquidity Strengthened and Funding Secured
Year-end liquidity comprised CHF 89 million cash on hand plus access to CHF 80 million from a new money facility (total available liquidity CHF 169 million). Secured a CHF 150 million funding facility, drew CHF 70 million, and raised CHF 68 million net via equity.
Material Cost Savings and Balance Sheet Improvements
Cost rationalization delivered savings of >CHF 80 million versus 2024. Negotiations reduced Idorsia's cost-sharing commitments by USD 100 million, generating a CHF 90 million gain in Q1 2025.
TRYVIO/JERAYGO Approvals and Clinical Differentiation
Aprocitentan (TRYVIO/JERAYGO) received approvals in the U.S., EU and additional markets; REMS requirement removed in March 2025; incorporated into updated ACC/AHA hypertension guidelines in August 2025. Pivotal PRECISION trial demonstrated double‑digit BP reduction of 15.4 mmHg in 4 weeks with favorable safety profile.
Early Real-World Uptake for TRYVIO
TRYVIO is being prescribed at >25 top hypertension centers during prelaunch activities, with increasing new patient starts and improving refill rates; smooth prior authorization reported for target segments.
Pipeline Progress and Clear Regulatory Path for Lucerastat
Advanced three chemokine receptor antagonists into clinical testing (CCR6 enrolling in psoriasis; CXCR7 study in-progress with MS to start; CXCR3 for vitiligo planned). Established an agreed development plan with regulators for lucerastat in Fabry disease, including a pivotal baseline-controlled biopsy study and a switch study, aiming for potential NDA submission as early as 2029.
QUVIVIQ Global Market Expansion & Local Wins
Public reimbursement wins in multiple markets (France, Germany, U.K., private insurance in Switzerland and Canada) and additional reimbursments (Austria, Germany premium price, negotiations in Quebec); strong demand in Q4 2025 with demand increases of 25% in Germany, 38% in Canada and 45% in the U.K. (quarterly comparisons). Significant uptake in China via partner Simcere with 300k–400k patients treated in first 6 months in private setting.
Pediatric Daridorexant Study Completed
Recruitment completed for pediatric (age 10–18) daridorexant trial; data expected early Q2 2026 — potential to be the first pediatric insomnia treatment and to support U.S. safety halo relevant for descheduling efforts.