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Cognition Therapeutics (CGTX)
NASDAQ:CGTX
US Market

Cognition Therapeutics (CGTX) AI Stock Analysis

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Cognition Therapeutics

(NASDAQ:CGTX)

Rating:41Neutral
Price Target:
Cognition Therapeutics is currently facing major financial challenges with persistent losses and cash flow issues. Technical indicators provide mixed signals with short-term momentum but long-term caution. Valuation remains a concern with negative earnings and no dividend yield. Although the earnings call highlighted some strategic progress, significant concerns like NASDAQ compliance and uncertain funding overshadow these advancements. Overall, the stock is a high-risk investment with potential for future improvement if financial and strategic objectives are met.
Positive Factors
Clinical trial progress
Cognition Therapeutics announced that the Phase 2 ‘START’ Study had surpassed 50% enrollment.
Market potential
DLB could represent a blockbuster or near-blockbuster indication, with roughly $1B in peak annual sales for zervimesine in the U.S. alone.
Regulatory milestones
Receipt of Breakthrough Therapy Designation status in DLB for zervimesine and confirmation that a single pivotal trial would be sufficient for regulatory submission are seen as meaningful inflection points.
Negative Factors
Equity dilution
Lowering the 12-month price target to $3 from $5 reflects anticipated equity dilution.
Financial outlook
Cognition Therapeutics ended 1Q25 with ~$16.4M in cash, which is sufficient to fund operations only into late 2025.

Cognition Therapeutics (CGTX) vs. SPDR S&P 500 ETF (SPY)

Cognition Therapeutics Business Overview & Revenue Model

Company DescriptionCognition Therapeutics, Inc., a clinical-stage biopharmaceutical company, engages in the discovery and development of small molecule therapeutics targeting age-related degenerative diseases and disorders of the central nervous system and retina. Its lead product candidate is CT1812, a sigma-2 receptor antagonist, which is in Phase II clinical trial for the treatment of mild-to-moderate Alzheimer's disease, as well as has completed Phase I clinical trial to treat early-stage Alzheimer's disease; in Phase II clinical trial for the treatment of dementia with Lewy bodies (DLB); and in preclinical trial to treat dry age-related macular degeneration (AMD). The company is also developing CT2168 for the treatment of synucleinopathies, which include DLB and Parkinson's disease; and CT2074 to treat dry AMD. Cognition Therapeutics, Inc. was incorporated in 2007 and is headquartered in Purchase, New York.
How the Company Makes MoneyCognition Therapeutics makes money primarily through the development and eventual commercialization of its pharmaceutical products. The company generates revenue by advancing its drug candidates through clinical trials, aiming for successful regulatory approval, which can lead to product sales, licensing agreements, or partnerships with larger pharmaceutical companies. These collaborations can result in milestone payments, royalties, and upfront fees. Additionally, the company may receive government grants or public funding to support its research and development efforts in targeting Alzheimer's and other neurodegenerative diseases.

Cognition Therapeutics Earnings Call Summary

Earnings Call Date:May 07, 2025
(Q4-2024)
|
% Change Since: 66.67%|
Next Earnings Date:Aug 12, 2025
Earnings Call Sentiment Neutral
The earnings call highlights significant progress in clinical efficacy signals and strategic cost management, extending the cash runway. However, challenges remain with increased net losses, NASDAQ compliance issues, and uncertain funding partnerships. The sentiment is balanced by advancements in manufacturing and patent filings.
Q4-2024 Updates
Positive Updates
Strong Efficacy Signals for Zervimesine
The company reported strong efficacy signals from two studies involving Alzheimer's disease and dementia with Lewy bodies (DLB), indicating potential value for patients and investors.
Cash Runway Extension
The strategic decision to conclude the Phase II dry AMD study is projected to result in cost savings that extend the company's cash runway into the fourth quarter of 2025.
Provisional Patent Applications Filed
Cognition Therapeutics has filed provisional patent applications for a novel chemical process developed for the manufacture of zervimesine, supporting future clinical studies and potential commercial manufacturing.
Progress in Manufacturing Capabilities
The company is working with a domestic contract manufacturing organization capable of producing commercial quantities of zervimesine, positioning them for potential future market demands.
Negative Updates
Net Loss Increase
The company reported a net loss of $34 million for the year ended December 31, 2024, compared to a net loss of $25.8 million in 2023, despite a decrease in general and administrative expenses.
NASDAQ Compliance Challenge
The company has been granted a six-month grace period to regain compliance with NASDAQ's minimum bid requirement, needing the stock to close above $1 for ten consecutive days before September 8, 2025.
Uncertain Partnership and Funding
Despite ongoing discussions, there is no confirmed partnership or assurance of non-dilutive funding for the development and registration program, which remains a critical need for advancing trials.
Company Guidance
During the Cognition Therapeutics Fourth Quarter and Full Year 2024 Earnings Call, the company provided guidance on advancing their lead candidate, zervimesine (CT1812), into registrational trials for Alzheimer's disease and dementia with Lewy bodies (DLB). The company plans to submit final study documents to the FDA and request end of Phase II meetings for both indications. Their strategic decision to conclude the Phase II dry AMD study was made to focus resources on Alzheimer's and DLB programs, extending their cash runway into Q4 2025. Cognition reported a net loss of $34 million for 2024 and utilized an ATM facility to raise $12.8 million. They hold approximately $25 million in cash and $50 million in obligated grant funds. The company is also working on securing non-dilutive funding and is confident in regaining NASDAQ compliance within the allotted grace period.

Cognition Therapeutics Financial Statement Overview

Summary
Cognition Therapeutics is facing significant financial challenges, with no revenue generation and increasing operational losses. The balance sheet reflects a precarious financial position with past negative equity and ongoing liabilities. Cash flow analysis indicates critical cash management issues, with persistent negative free cash flow. Overall, the company needs strategic financial restructuring and revenue generation to stabilize its financial health.
Income Statement
10
Very Negative
Cognition Therapeutics has shown persistent negative profitability with no revenue reported over the years. The EBIT and EBITDA margins are negative, indicating operational challenges. The net income has also been negative throughout, with increasing losses, which presents concerns regarding the company's profitability trajectory.
Balance Sheet
25
Negative
The balance sheet shows a decreasing equity base and increasing liabilities, leading to concerns about financial stability. The company's debt-to-equity ratio is not applicable due to negative equity in past years, but the current positive equity is a slight improvement. However, the company's reliance on debt financing remains a potential risk.
Cash Flow
30
Negative
The cash flow statement reveals consistent negative free cash flow, indicating operational cash burn. While there is some financing inflow, the operating cash flow to net income ratio is negative, further highlighting cash flow challenges. The growth in free cash flow is not visible, suggesting ongoing cash management issues.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.000.000.000.000.00
Gross Profit-67.00K0.00-252.00K-235.00K-93.00K-98.00K
EBITDA-38.37M-33.68M-25.51M-21.13M-13.38M-5.99M
Net Income-33.30M-33.97M-25.79M757.00K-10.29M-10.07M
Balance Sheet
Total Assets23.50M30.23M35.16M50.42M59.14M7.12M
Cash, Cash Equivalents and Short-Term Investments16.43M25.01M29.92M41.56M54.72M5.19M
Total Debt474.00K814.00K1.24M1.48M0.0012.85M
Total Liabilities11.23M11.48M10.69M10.18M7.86M75.30M
Stockholders Equity12.27M18.75M24.47M40.25M51.27M-68.18M
Cash Flow
Free Cash Flow-31.11M-28.48M-16.16M-18.70M-3.66M-3.44M
Operating Cash Flow-31.11M-28.47M-16.02M-18.53M-3.63M-3.43M
Investing Cash Flow-4.00K-4.00K-147.00K-171.00K-27.00K-10.00K
Financing Cash Flow12.87M23.57M4.52M5.55M53.20M5.76M

Cognition Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price0.70
Price Trends
50DMA
0.34
Positive
100DMA
0.39
Positive
200DMA
0.47
Positive
Market Momentum
MACD
0.07
Negative
RSI
79.10
Negative
STOCH
70.64
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CGTX, the sentiment is Positive. The current price of 0.7 is above the 20-day moving average (MA) of 0.37, above the 50-day MA of 0.34, and above the 200-day MA of 0.47, indicating a bullish trend. The MACD of 0.07 indicates Negative momentum. The RSI at 79.10 is Negative, neither overbought nor oversold. The STOCH value of 70.64 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for CGTX.

Cognition Therapeutics Risk Analysis

Cognition Therapeutics disclosed 85 risk factors in its most recent earnings report. Cognition Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Cognition Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (64)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
64
Neutral
¥341.99B10.89-2.99%2.57%11.76%-9.96%
41
Neutral
$33.00M-161.93%-0.38%
$17.15M-137.33%
58
Neutral
$22.51M-167.57%127.51%71.16%
35
Underperform
$49.30M-280.78%68.75%
33
Underperform
$22.07M-112.99%57.93%
30
Underperform
$50.38M-2880.11%31.09%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CGTX
Cognition Therapeutics
0.70
-1.13
-61.75%
LEXX
Lexaria Bioscience
0.90
-1.91
-67.97%
CMMB
Chemomab Therapeutics
1.16
0.02
1.75%
ANVS
Annovis Bio
2.85
-10.26
-78.26%
LGVN
Longeveron
1.50
-2.39
-61.44%
NRSN
Neurosense Therapeutics Ltd.
2.11
1.08
104.85%

Cognition Therapeutics Corporate Events

Product-Related AnnouncementsBusiness Operations and Strategy
Cognition Therapeutics Shows Promising Phase 2 Study Results
Positive
Jan 13, 2025

Cognition Therapeutics announced promising results from their Phase 2 SHIMMER study, which highlighted the efficacy and safety of their lead product, zervimesine, in treating dementia with Lewy bodies (DLB). The study showed strong responses across behavioral, functional, cognitive, and movement measures, positioning zervimesine as a potential first-to-market treatment for DLB, further supported by robust intellectual property and a favorable safety profile.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: May 02, 2025