Combination Therapy And Lean Mass PreservationPreclinical and early clinical signals that icovamenib enhances GLP‑1 activity while preserving lean mass suggest potential value as a combination approach to improve weight and metabolic outcomes without worsening muscle loss.
Disease-modifying EfficacySustained increases in C-peptide and persistent HbA1c improvements after treatment discontinuation support the potential for a disease‑modifying profile in insulin‑deficient diabetes patients.
Targeted Clinical Response In SIDD And Post-GLP-1 PatientsClinically meaningful HbA1c reductions observed in severe insulin‑deficient and post‑GLP‑1 nonresponder cohorts indicate targeted benefit in hard‑to‑treat type 2 diabetes subtypes and strengthen the case for focused Phase 2 trials.