Clinical Trial ResultsBiomea announced positive topline results from the Phase 2 COVALENT-111 clinical trial evaluating icovamenib in patients with T2D.
Efficacy And SafetyIcovamenib exhibited a mean HbA1c reduction of 1.47% and a 53% increase in C-peptide after 14 weeks off-therapy, with no safety concerns.
Synergistic PotentialInitial preclinical data shows icovamenib synergizes with GLP-1 RAs for glucose control, indicating potential benefits in diabetes treatment.