Exceptional Full-Year Growth and Profitability
Full year 2025 revenue $305.1M, up 100% year-over-year; achieved GAAP operating income of $16.0M (operating profit margin 5%) and adjusted EBITDA $38.8M (13% margin); positive cash flow from operations minus capex $16M for full year.
Fourth Quarter Acceleration
Q4 2025 revenue $96.1M, up 113% year-over-year; Q4 operating income $10.3M (11% operating margin); Q4 net income $4.4M ($0.11/diluted share).
Rapid Volume and ASP Expansion
Total tests delivered in 2025 were 610,000, up 51% year-over-year; overall ASP increased 35% to $495 for the full year and sequentially rose from $501 to $561 in Q4 (+12% quarter-over-quarter; +$60/test).
Strong Gross Margin Improvement
Company expanded gross margins to 71.4% in Q4 (up 14.3 percentage points year-over-year) driven by higher ASPs and lower COGS per test; full-year gross margins improved meaningfully vs prior year.
Oncology Ramp and Product Innovation
Oncology revenue grew to $9.1M in Q4 (+736% year-over-year), achieving a $36M oncology annualized run-rate; launched Northstar PGx and Northstar Select CH and submitted Northstar Response coverage dossier to MolDX.
Prenatal Leadership and Clinical Adoption
Prenatal revenue $86.9M in Q4 (+98% year-over-year) with a $348M prenatal annualized run-rate; UNITY Fetal Antigen NIPT supported by new MFM guideline and launched expanded Red Blood Cell Antigen and first-ever Platelet Fetal Antigen NIPT.
Payer Contracts and Major In-Network Win
Signed 44 payer contracts in 2025 adding >25M lives and reaching ~250M contracted US lives; announced in‑network contract with UnitedHealthcare effective April 1, 2026 (expected to reduce friction and improve realized ASPs).
Balance Sheet Strength
Ended year with ~$496M cash and equivalents and only ~$50M term debt, providing runway to fund growth and evidence generation.
Operational Efficiency and Capacity
Reported >10% reduction in COGS per test year-over-year (company also noted ongoing AI/automation deployment); operating productivity improved materially (36 percentage point improvement in GAAP operating margin year-over-year).
Raised 2026 Guidance
Raised 2026 revenue guidance to $430M–$445M (implying 41%–46% growth vs 2025) and reiterated expectation for positive GAAP operating income for 2026.