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Paradigm Biopharmaceuticals Ltd. (AU:PAR)
ASX:PAR

Paradigm Biopharmaceuticals (PAR) AI Stock Analysis

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AU:PAR

Paradigm Biopharmaceuticals

(Sydney:PAR)

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Neutral 46 (OpenAI - 5.2)
Rating:46Neutral
Price Target:
AU$0.32
▼(-2.12% Downside)
The score is primarily constrained by weak financial performance—minimal/volatile revenue, continued losses, and ongoing cash burn—partly offset by very low balance-sheet leverage and an improving FY2025 loss/burn profile. Technicals are neutral-to-soft with a negative MACD and price below the 50-day average, and valuation is limited by negative earnings and no dividend support.
Positive Factors
Clinical Trial Progress
The progress in the Phase 3 trial for knee osteoarthritis indicates potential for future revenue growth and market expansion, enhancing long-term business prospects.
Funding and Financial Strategy
The additional funding through convertible notes strengthens the company's financial position, ensuring capital availability for strategic initiatives and clinical trials.
Global Clinical Expansion
Expanding clinical trials globally enhances Paradigm's market presence and data quality, potentially improving regulatory outcomes and commercial success.
Negative Factors
Cash Flow Challenges
Persistent negative cash flow indicates reliance on external funding, which may limit financial flexibility and impact long-term sustainability.
Revenue Volatility
Volatile and minimal revenue highlights challenges in achieving stable income streams, affecting the company's ability to scale operations effectively.
Negative Profitability
Sustained negative profitability underscores operational inefficiencies and challenges in cost management, impacting long-term financial health.

Paradigm Biopharmaceuticals (PAR) vs. iShares MSCI Australia ETF (EWA)

Paradigm Biopharmaceuticals Business Overview & Revenue Model

Company DescriptionParadigm Biopharmaceuticals Limited, a drug repurposing company, engages in the research and development of therapeutic products for human use in Australia. It offers pentosan polysulfate sodium drugs in the injectable form for the treatment of osteoarthritis, mucopolysaccharidosis, ross river virus, chikungunya virus, and acute respiratory distress syndrome diseases. The company was incorporated in 2014 and is based in Melbourne, Australia.
How the Company Makes MoneyParadigm Biopharmaceuticals Ltd. makes money primarily through the development and commercialization of its proprietary therapeutic products. The company's revenue model is based on advancing its drug candidates through clinical trials and obtaining regulatory approvals. Once approved, Paradigm can generate revenue through licensing agreements, collaborations, and partnerships with larger pharmaceutical companies for the distribution and marketing of its products. Additionally, the company may earn revenue from milestone payments and royalties from sales of its approved drugs. Key factors contributing to its earnings include successful clinical trial results, strategic partnerships, and favorable regulatory outcomes.

Paradigm Biopharmaceuticals Financial Statement Overview

Summary
Paradigm Biopharmaceuticals Ltd. demonstrates financial instability with ongoing losses, negative cash flows, and a diminishing asset base. Despite a low debt-to-equity ratio offering some stability, negative operating cash flow and profitability metrics pose significant risks.
Income Statement
Paradigm Biopharmaceuticals Ltd. has shown an inconsistent revenue stream with fluctuations over the years. The gross profit margin is very low, and the company has consistently reported negative net and EBIT margins, indicating ongoing losses. Revenue growth is modest but overshadowed by substantial operating losses, limiting the financial stability of the company.
Balance Sheet
The company's balance sheet reflects moderate financial stability with a low debt-to-equity ratio, suggesting limited leverage use. However, the equity ratio has decreased over time, and the company has a negative return on equity (ROE), indicating that it is not generating profits from its equity base. The overall asset base has diminished, reflecting potential operational challenges.
Cash Flow
Paradigm Biopharmaceuticals Ltd. faces significant cash flow challenges with consistent negative operating and free cash flows. The free cash flow growth rate is negative, showing worsening cash flow conditions. High operating cash flow losses relative to net income further demonstrate liquidity issues, impacting the company's ability to reinvest or expand.
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue52.12K52.12K65.80K46.76K79.22K20.55K
Gross Profit-48.42K-19.89K56.81K-18.83K-64.53K-78.59K
EBITDA-25.24M-25.25M-64.54M-59.06M-46.82M-42.40M
Net Income-18.77M-18.77M-58.65M-51.91M-39.25M-34.30M
Balance Sheet
Total Assets24.57M24.57M27.39M67.07M50.69M84.79M
Cash, Cash Equivalents and Short-Term Investments16.82M16.82M17.87M56.38M39.72M71.08M
Total Debt5.48K5.48K239.33K341.67K616.67K751.84K
Total Liabilities3.39M3.39M3.58M13.39M8.38M6.52M
Stockholders Equity21.18M21.18M23.81M53.68M42.31M78.27M
Cash Flow
Free Cash Flow-15.99M-15.99M-65.94M-45.19M-32.21M-34.96M
Operating Cash Flow-15.99M-15.99M-65.94M-45.19M-32.21M-34.93M
Investing Cash Flow46.20K46.20K0.000.000.00668.37K
Financing Cash Flow14.99M14.99M28.18M62.53M70.12K1.00M

Paradigm Biopharmaceuticals Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price0.33
Price Trends
50DMA
0.36
Negative
100DMA
0.34
Positive
200DMA
0.34
Positive
Market Momentum
MACD
<0.01
Negative
RSI
50.09
Neutral
STOCH
78.57
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AU:PAR, the sentiment is Neutral. The current price of 0.33 is above the 20-day moving average (MA) of 0.33, below the 50-day MA of 0.36, and below the 200-day MA of 0.34, indicating a neutral trend. The MACD of <0.01 indicates Negative momentum. The RSI at 50.09 is Neutral, neither overbought nor oversold. The STOCH value of 78.57 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for AU:PAR.

Paradigm Biopharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
AU$114.16M-1.11-83.09%55.94%
46
Neutral
AU$154.27M-6.84-81.03%-20.79%73.98%
44
Neutral
AU$196.64M-7.550.66%
44
Neutral
AU$111.71M-13.24-47.98%700.00%26.88%
41
Neutral
AU$97.88M-5.26-42.68%63.46%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AU:PAR
Paradigm Biopharmaceuticals
0.34
-0.10
-23.60%
AU:IMU
Imugene
0.35
-1.15
-76.60%
AU:ATH
Alterity Therapeutics
0.01
>-0.01
-44.44%
AU:NUZ
Pharmaust Limited
0.08
-0.08
-50.62%
AU:RCE
Recce Pharmaceuticals Ltd.
0.68
0.22
46.24%
AU:ALA
Arovella Therapeutics Limited
0.09
-0.08
-48.57%

Paradigm Biopharmaceuticals Corporate Events

Paradigm Nears 25% Recruitment Milestone in Pivotal Knee Osteoarthritis Phase 3 Trial
Dec 22, 2025

Paradigm Biopharmaceuticals has confirmed it has enrolled or randomised enough patients to meet the 25% recruitment threshold in its pivotal global Phase 3 PARA_OA_012 trial of injectable pentosan polysulfate sodium for knee osteoarthritis, with some participants scheduled to begin dosing after the holiday period to safeguard protocol compliance over the six-week regimen. The company reports strong screening activity, boosted by a targeted Medimark-led outreach campaign in Australia that has generated thousands of pre-screened leads, and expects recruitment momentum to accelerate as more sites, including new centres in Moldova and Hong Kong, become fully active, keeping interim analysis timing for mid-2026 and full primary endpoint read-out in late 2026 in line with prior guidance, a key marker for the program’s progress and future commercial prospects.

The most recent analyst rating on (AU:PAR) stock is a Buy with a A$0.65 price target. To see the full list of analyst forecasts on Paradigm Biopharmaceuticals stock, see the AU:PAR Stock Forecast page.

Paradigm Biopharmaceuticals’ AGM Resolutions Passed Successfully
Nov 19, 2025

Paradigm Biopharmaceuticals Limited announced the successful passing of all resolutions during its 2025 Annual General Meeting. Key resolutions included the adoption of the remuneration report, re-election of a director, approval of convertible notes issuance, and renewal of takeover provisions. These decisions are expected to strengthen the company’s governance and financial strategies, potentially enhancing its market position and stakeholder confidence.

The most recent analyst rating on (AU:PAR) stock is a Buy with a A$0.65 price target. To see the full list of analyst forecasts on Paradigm Biopharmaceuticals stock, see the AU:PAR Stock Forecast page.

Paradigm Biopharmaceuticals Secures Additional Funding Through Convertible Notes
Nov 17, 2025

Paradigm Biopharmaceuticals has issued a Cleansing Notice related to the issuance of convertible notes, allowing for the conversion of these notes into fully paid ordinary shares that can be sold to retail investors without further disclosure. The company has secured commitments for up to US$27 million through a Convertible Securities Agreement with Obsidian Global GP LLC, with an initial drawdown of US$7 million and a recent additional drawdown of US$5 million. This financial maneuver is expected to impact the company’s operations by providing capital for growth and enhancing its market positioning.

The most recent analyst rating on (AU:PAR) stock is a Buy with a A$0.65 price target. To see the full list of analyst forecasts on Paradigm Biopharmaceuticals stock, see the AU:PAR Stock Forecast page.

Paradigm Biopharmaceuticals Issues 5 Million Convertible Notes
Nov 17, 2025

Paradigm Biopharmaceuticals Limited announced the issuance of 5,000,000 unquoted convertible notes as part of a previously disclosed transaction. This move is part of the company’s strategic financial operations, potentially impacting its capital structure and providing additional resources for its ongoing projects.

The most recent analyst rating on (AU:PAR) stock is a Buy with a A$0.65 price target. To see the full list of analyst forecasts on Paradigm Biopharmaceuticals stock, see the AU:PAR Stock Forecast page.

Paradigm Biopharmaceuticals Secures Funding for Global Clinical Expansion
Nov 17, 2025

Paradigm Biopharmaceuticals has completed a US$5 million drawdown under its US$27 million Convertible Note Facility with Obsidian Global Partners. This funding will support the company’s global Phase 3 clinical trial for knee osteoarthritis, as it expands operations with new trial sites in Europe and Asia. The drawdown ensures Paradigm remains well-capitalized during this period of increased clinical activity, with US$15 million still available for future needs. The company maintains disciplined financial management to align investments with trial progress, ensuring funding through key milestones, including an interim analysis in mid-2026.

The most recent analyst rating on (AU:PAR) stock is a Buy with a A$0.65 price target. To see the full list of analyst forecasts on Paradigm Biopharmaceuticals stock, see the AU:PAR Stock Forecast page.

Paradigm Biopharmaceuticals Announces Change in Substantial Shareholder Status
Nov 12, 2025

Paul Rennie, a significant shareholder in Paradigm Biopharmaceuticals, has ceased to be a substantial holder as of October 30, 2025, due to dilution from the conversion of convertible notes. This change affects over 20 million ordinary shares, impacting the company’s shareholder structure and potentially its market positioning.

The most recent analyst rating on (AU:PAR) stock is a Buy with a A$0.65 price target. To see the full list of analyst forecasts on Paradigm Biopharmaceuticals stock, see the AU:PAR Stock Forecast page.

Paradigm Biopharmaceuticals Expands Global Phase 3 Trial with New Sites
Nov 11, 2025

Paradigm Biopharmaceuticals has engaged Nordic Bioscience Clinical Development (NBCD) A/S as a complementary contract research organization to support its pivotal Phase 3 clinical trial for knee osteoarthritis. This collaboration will activate four new clinical sites in Hong Kong and Moldova, enhancing the trial’s global footprint and aligning with Hong Kong’s new ‘1+’ regulatory pathway. The strategic expansion is expected to bolster Paradigm’s commercial readiness and data robustness, with recruitment set to commence in January 2026. The initiative aims to strengthen Paradigm’s scientific and operational foundations, offering potential regulatory and commercial flexibility in the Greater Bay Area and improving data quality with diverse patient populations.

The most recent analyst rating on (AU:PAR) stock is a Buy with a A$0.65 price target. To see the full list of analyst forecasts on Paradigm Biopharmaceuticals stock, see the AU:PAR Stock Forecast page.

Paradigm Biopharmaceuticals Issues 3 Million Unlisted Options
Nov 7, 2025

Paradigm Biopharmaceuticals Limited announced the issuance of 3,000,000 unlisted options as part of a previously disclosed transaction. These securities are unquoted and not intended for quotation on the ASX, reflecting the company’s strategic financial maneuvers to support its ongoing operations and growth initiatives.

The most recent analyst rating on (AU:PAR) stock is a Buy with a A$0.65 price target. To see the full list of analyst forecasts on Paradigm Biopharmaceuticals stock, see the AU:PAR Stock Forecast page.

Paradigm Biopharmaceuticals Announces 2025 Annual General Meeting Details
Oct 20, 2025

Paradigm Biopharmaceuticals announced the details of its upcoming annual general meeting, scheduled for November 19, 2025, to be held both in-person and virtually. Shareholders are encouraged to participate by submitting proxy forms and questions in advance, with the company providing online resources to facilitate engagement. This move reflects the company’s commitment to shareholder engagement and transparency, potentially impacting its operational strategies and stakeholder relations positively.

The most recent analyst rating on (AU:PAR) stock is a Buy with a A$0.65 price target. To see the full list of analyst forecasts on Paradigm Biopharmaceuticals stock, see the AU:PAR Stock Forecast page.

Paradigm Biopharmaceuticals Expands Market Presence with New Securities Quotation
Oct 8, 2025

Paradigm Biopharmaceuticals Limited has announced the quotation of 11,714,207 ordinary fully paid securities on the Australian Securities Exchange (ASX) as of October 8, 2025. This move is part of the company’s strategic efforts to enhance its financial flexibility and support its ongoing development projects, potentially strengthening its market position and offering new opportunities for stakeholders.

The most recent analyst rating on (AU:PAR) stock is a Buy with a A$0.65 price target. To see the full list of analyst forecasts on Paradigm Biopharmaceuticals stock, see the AU:PAR Stock Forecast page.

Paradigm Biopharmaceuticals Advances Phase 3 iPPS Trial for Knee Osteoarthritis
Sep 30, 2025

Paradigm Biopharmaceuticals has reached a significant milestone in its Phase 3 clinical trial for iPPS, a treatment for knee osteoarthritis, by dosing participants in both the United States and Australia. The trial, which aims to evaluate the efficacy and safety of iPPS, has shown improved screening results due to refined eligibility criteria guided by the FDA. With nearly all sites expected to be activated by the end of October, the company is on track to meet its enrolment targets and deliver an interim analysis by mid-2026, potentially impacting its market position and stakeholder value.

The most recent analyst rating on (AU:PAR) stock is a Buy with a A$0.73 price target. To see the full list of analyst forecasts on Paradigm Biopharmaceuticals stock, see the AU:PAR Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 30, 2025