Strong Revenue Growth (Full Year)
Net product revenues for full year 2025 were $372.1 million, a 123% increase versus 2024, driven primarily by ZORYVE demand across indications.
Record Fourth Quarter Performance
Q4 2025 net product revenues were $127.5 million, up 84% year-over-year and 29% sequentially from Q3 2025; sequential growth driven by a 19% increase in prescription volume in the quarter.
Prescription Momentum and Market Share
Total prescription volume roughly doubled year-over-year in 2025; weekly prescriptions (4-week rolling average) reached ~22,000 scripts. ZORYVE holds ~45% share of branded nonsteroidal topical prescription volume.
Regulatory and Label Expansion Progress
FDA approvals in 2025 included ZORYVE foam 0.3% for scalp and body psoriasis (12+) and ZORYVE cream 0.05% for atopic dermatitis in children 2–5. sNDA submitted for ZORYVE cream 0.3% in psoriasis ages 2–5 with a PDUFA date of June 29, 2026.
Positive Pediatric Phase II Results (INTEGUMENT-INFANT)
Phase II infants (3–24 months) topline: 58% achieved EASI-75 at week 4 and ~33% reached EASI-75 by week 2. No treatment-emergent serious adverse events and only one discontinuation; plan to submit sNDA in Q2 2026.
Pipeline Expansion and New Programs
Initiated Phase II proof-of-concept studies for ZORYVE foam 0.3% in vitiligo and hidradenitis suppurativa (HS); IND submitted for ARQ-234 (novel biologic) with Phase I dosing expected soon.
Improved Profitability and Cash Flow
Company achieved positive cash flow from operations in Q4 2025 of $26.2 million and reported cash and marketable securities of $221.3 million as of Dec 31, 2025. Net loss for 2025 narrowed to $16.1 million vs. $140.0 million in 2024; Q4 net income was $17.4 million.
Commercial and Access Wins
Expanded commercial footprint (dermatology sales force +20% to ~160 reps) and built an initial primary care/pediatrics pilot (~30 reps). Access: >80% commercial formularies, >50% Medicaid with single-step edits, and ~1/3 of Medicare Part D plans covering ZORYVE (only branded nonsteroidal topical on some Medicare formularies).
Raised 2026 Revenue Guidance
Full year 2026 net product revenue guidance increased from $455–470 million to $480–495 million based on Q4 momentum and planned investments.