Pivotal Phase II ALLO-501A Trial Progress
The ALLO-501A trial in large B cell lymphoma is advancing with 40 sites activated, showing strong community and academic enthusiasm. Anticipated key milestones include lymphodepletion selection and futility analysis by mid-2025.
Expansion into Autoimmune Diseases with ALLO-329
ALLO-329 received FDA clearance for Phase I trials, marking Allogene's official expansion into autoimmune diseases. The dual-targeting CAR T product candidate could potentially eliminate the need for lymphodepletion.
Encouraging Phase I Data for ALLO-316 in Renal Cell Carcinoma
ALLO-316 shows promise in renal cell carcinoma with a 50% best overall response rate. The program is positioned for potential strategic partnerships, with data updates expected mid-2025.
Strong Financial Position
Allogene reported $373.1 million in cash reserves with a cash runway extending into the second half of 2026. The company maintains capital discipline, preparing for strategic growth.