Efficacy DataThe AL001-treated cohort demonstrated a 48% reduction in the annual progression rate of CDR plus NACC FTLD-SB scores compared to matched GENFI controls, reinforcing the potential efficacy of the treatment.
Financial Stability$307 million cash will last into the second half of 2027, providing a strong financial runway.
Trial DesignThe study is >99% powered for the new co-primary endpoint, and prior open-label data showed normalization of both plasma and CSF PGRN, providing confidence that this endpoint will be met.