Strong Liquidity Position
Approximately $561 million in cash, cash equivalents and marketable securities at quarter end, with an additional ~$140 million in committed government funding, yielding roughly $700 million in total available liquidity to execute the strategy.
Transition to Clinical-Stage Biotech and Pipeline Expansion
Successfully delivered on four corporate priorities for 2025 and exceeded one by nominating two development candidates. ABCL635 advanced into a randomized, double-blind, placebo-controlled Phase II study; ABCL575 is in Phase I; ABCL688 and ABCL386 are in IND‑enabling activities. More than 20 programs in discovery and an expectation to advance a fifth program into IND-enabling activities in H1 2026.
Near- and Mid-Term Clinical Catalysts
Management expects 2 clinical readouts in 2026 (including ABCL635 Phase II readout anticipated in Q3 2026) and plans for multiple catalysts in 2027 with an anticipated five clinical-stage programs by mid-2027.
Revenue Increase Year-over-Year
Total revenue for 2025 was $75 million versus ~$29 million in 2024, an increase of approximately 158.6%, driven largely by $36 million from a patent settlement with Bruker and $47 million in licensing and royalty payments (and $27 million from partnered program work).
Improved Net Loss and EPS Trend
Net loss improved to approximately $146 million in 2025 from about $163 million in 2024, representing a reduction in loss of ~10.4%. Reported loss per share was $0.49 (basic and diluted).
Increased R&D Investment to Support Internal Pipeline
Research and development expenses rose to $187 million in 2025, about $20 million higher than the prior year (~+12%), reflecting deliberate investment in advancing proprietary programs and internal capabilities.
Clinical Manufacturing and Capital Investments
Substantial completion of clinical manufacturing facility and continued PP&E investments to establish clinical manufacturing capabilities, intended to improve supply chain control, flexibility and IP protection; real estate and other financing actions provided $63 million in liquidity during the quarter.
Discovery-to-Clinic Track Record
Cumulative total of 104 partner-initiated programs with downstream participation; 19 molecules discovered by or via licensed technology have reached the clinic. Of the 104 programs, management reported roughly 48 programs currently actively progressing (~46%).