Strong Revenue Growth
Q4 revenue of $121,000,000 and full-year 2025 revenue of $428,000,000. Management cites exome and genome revenue growth (CEO stated 54% for the year) and CFO reported total company revenue up 27% year-over-year.
Exome & Genome Volume and Organic Growth
Q4 exome/genome test results of 27,761 with a steady acceleration in quarterly volume growth (24% in Q1 → 29% Q2 → 33% Q3 → 34% Q4). CFO reports exome/genome revenues of $104,000,000; organic exome/genome revenue growth of 42% when excluding a $6.8M one-time payer recovery from prior-year Q4.
Improving Average Reimbursement Rate (ARR)
ARR for exome/genome approximately $3,750 in Q4 2025, up from $3,000 in 2024 and $2,500 in 2023 (~25% ARR increase 2024→2025 and 50% 2023→2025).
High and Improving Gross Margins
Total company adjusted gross margin of 71% for Q4 and full-year 2025, improving from 65% in 2024 and 45% in 2023; exome/genome portfolio operates at higher margins (management says combined exome/genome in the 80s).
Positive Adjusted Net Income
Adjusted net income of $4,400,000 for Q4 and $4,800,000 for full-year 2025, demonstrating operating leverage and profitability at the adjusted level.
Industry Leadership & Strategic Differentiators
Received FDA Breakthrough Device Designation; INFINITY dataset reported as the world's largest rare disease dataset with >2,500,000 rare genetic tests, >1,000,000 exomes/genomes, >8,000,000 phenotypic data points, >60% parental data and >50% non‑European descent—positioned as a durable competitive moat.
Operational & Clinical Execution
Turnaround times ~two weeks for exome/genome; proprietary AI tools (GeneMaker Multi) and INFINITY used to improve diagnostic yield and efficiency; CEO claims test accuracy advantage versus competitors (management states 'two times the accuracy' compared to another exome/genome).
Reaffirmed 2026 Guidance with Clear Growth Plan
2026 guidance reaffirmed: total revenues $540M–$555M; exome/genome volume growth guidance 33%–35%; expected adjusted gross margin ~70%; adjusted net income expected positive for full-year and each quarter; plan includes near-term investments (salesforce, CX, R&D) with operating margin building toward double digits by Q4.
Commercial Expansion & Talent Wins
Commercial footprint expansion: multiple hiring plans (management cited expanding salesforce significantly — references include expanding ~50 reps to 75 in specialty coverage, dedicating a 50-person pediatric sales team, 10 NICU reps, ~10 prenatal reps, plus mentions of adding ~100 reps in capacity planning). CEO also named to TIME 100 Health list (visibility/brand recognition).