Robust Volume Growth
Test result volume grew 34% year-over-year to 27,488 tests in Q1, demonstrating strong demand across foundational and expansion markets.
Exome & Genome Revenue Momentum
Exome and genome revenue was $90.6 million, up 27% year-over-year, reflecting successful penetration of higher-content tests despite mix dynamics.
Large and Differentiated Data Asset
GeneDx reported a contactable database with >2.5 million patients, >1 million exomes and genomes, and >8 million matched phenotypic profiles — a strategic moat for interpretation, payer engagement, and biopharma partnerships.
Healthy Gross Margins and Clear Path to Profitability
Adjusted gross margin was 69% in Q1 and management reiterated expected adjusted gross margins of ~70% for 2026, with a commitment to return to adjusted profitability by year-end and meaningful margin/profit expansion into 2027.
Commercial & Product Initiatives
Launched Reflex offering (Feb) to balance genome adoption and unit economics; expanded sales teams across specialists (≈75 reps), general pediatrics (≈50 reps), NICU (≈10 reps) and prenatal (≈10 reps) to accelerate adoption in key channels, and reported encouraging NICU traction and early general pediatrics ordering.
Updated Guidance with Line-of-Sight Execution
Revised full-year 2026 revenue guidance to $475M–$490M, with at least 30% exome & genome volume growth (~126,400 tests) and at least 20% exome & genome revenue growth; Q2 guidance set to $110M–$112M total revenue and ~30,000 exome/genome tests, indicating management confidence in near-term momentum.
Cost Discipline and Focused Investment
Taken decisive OpEx actions including a $25 million reduction/recalibration of planned spend for 2026 to prioritize three levers: grow utilization, optimize unit economics (ARR & COGS), and deliver leading products at scale.