Strong XTENVI Sales Growth
XTENVI net product sales of $145.4 million in Q1 2026, up more than 85% year-over-year, reflecting expanding ECP utilization and consistent patient outcomes.
Reaffirmed Full-Year Financial Guidance
Full-year 2026 guidance reiterated: net product sales of $670 million to $700 million, SG&A $545 million to $565 million (including ~$40 million stock-based comp), R&D $115 million to $135 million (including ~$20 million stock-based comp), and gross margins of approximately 93%.
Commercial Momentum — Prescriber and Prescribing Depth
Nearly half of the 15,000 target ECPs prescribed XTENVI at least once a week (up ~10% from Q4 2025), with increasing depth of prescribing and mid-to-high teens retreatment rates trending toward a steady-state target of ~20%.
Direct-to-Consumer (DTC) Performance and Digital Engagement
DTC campaign delivering ROI at the higher end of benchmarks; xtenvi.com high-value engagement (quiz completion, Find a Doctor) up nearly 40% quarter-over-quarter and millions of website visitors driving patient funnel expansion.
Pipeline Progress — Phase II Initiations
Initiated CALLIOPE, an approximately 700-participant Phase II trial of TPO5 for potential Lyme disease prevention (top-line data expected in 2027). Also initiated the Phase II CORE study for TPO4 in ocular rosacea with top-line data expected in 2027.
One-Time License Milestone and Regulatory Win in Greater China
License fees and collaboration revenues of $16.7 million in Q1, including a one-time $15 million regulatory milestone from Grand Pharma following approval of TPO3 for DB in Greater China—supporting future royalty potential and regional commercial expansion.
Commercial Execution and Sales Force Enhancements
Preparing to deploy Key Account Leaders (~17–20 hires) targeted to high-opportunity practices to further increase depth of prescribing; management expects incremental impact beginning in 3Q/2H 2026.
Competitive and Market Positioning
Management reports XTENVI outperformed peers on prescription trends (peers saw double-digit declines vs Tarsus' low-single-digit declines in comparable metrics) and entering Q2 prescriptions rebounded to all-time highs.