Strong Full-Year Revenue Growth
Total revenue of $256 million in 2025, representing 23% year-over-year growth.
Software Business Scale
Software revenue of $199.5 million and software ACV of $198.5 million (approx $200M ACV in 2025); full-year software revenue increased ~11% year-over-year.
Drug Discovery Momentum
Drug discovery revenue of $56.4 million in 2025 (more than doubled year-over-year); drug discovery guidance for 2026 of $55M–$65M and a long-term target of ~$50M annual revenue.
Improved Profitability Trends and Cost Discipline
Net loss narrowed to $103 million in 2025 from $187 million in 2024; total operating expenses decreased ~9% to $310 million, reflecting 2025 cost reduction actions.
Strong Cash Position
Cash balance of approximately $402 million (described as 'over $400M'), supporting planned investments and the path to positive adjusted EBITDA by 2028.
Top-Customer and Commercial ACV Expansion
Total ACV increased to $198.5M from $190.8M (4% growth). Top 20 pharma ACV grew 15%; commercial ACV grew 7% to $177.4M; average ACV for $1M+ commercial cohort rose 16% to $3.9M.
Product & Pipeline Advances
Expanded platform capabilities (biologics, materials), released predictive toxicology beta, progressing internal programs (SGR-1505/3515 Phase I), expected initial Phase I data for Wee1/Myt1 in Q2, and continued advancement of collaborator programs.
Material Partnership & Portfolio Value
Portfolio now has 16 programs eligible for royalties (high-single to low-double-digit royalties), ~7 clinical programs (Phase I–III), >25 active programs across the ecosystem, ~$650M realized in cash/upfronts/milestones to date and up to $5B in potential future milestones.
Strategic Hosted Transition and New KPIs
23% of 2025 software revenue was hosted; company announced accelerated transition to hosted contracts with a goal of ~75% hosted software revenue by 2028 and introduced ACV-focused guidance (2026 ACV $218M–$228M, 10%–15% growth).