Annual Contract Value (ACV) Growth
ACV of $28.4 million in Q1 2026, a 12% increase year-over-year from $25.4 million in Q1 2025. Full-year ACV guidance maintained at $218M–$228M (10%–15% growth). Q2 ACV guide $19M–$23M (excludes contribution ACV).
Strong Drug Discovery Revenue Surge
Drug discovery revenue of $22.9 million in Q1 2026 versus $10.2 million in Q1 2025 — approximately +124% year-over-year, driven by accelerated recognition of deferred revenue from collaboration progress.
Total Revenue and Software Mix
Total revenue of $58.6 million for the quarter. Software revenue was $35.6 million, with hosted revenue contributing $12.1 million (34% of software revenue in Q1 2026 vs 24% in 2025); trailing four-quarter hosted revenue was 27% of software revenue.
Progress on Hosted Licensing Transition
Broad-based growth from usage scale-ups, new customers and new products. Transition to hosted licensing showing early positive conversion dynamics (34% hosted in the quarter, target to reach ~75% hosted over three years), and some multiyear on-premise contracts were converted to hosted ahead of renewal.
Bunsen — Agentic AI Co-Scientist Launch
Announced early access release of Bunsen (agentic AI) this summer. Internal use reported to materially improve productivity and throughput; expected to drive higher utilization of compute-heavy workflows and support throughput-based licensing upside.
Therapeutics & Corporate Transactions Validate Platform
Lilly's announced $2.3 billion acquisition of Ajax Therapeutics (a co-founded company) highlights platform impact; Schrödinger holds ~6% equity in Ajax. Company reports seven major transactions/exits across co-discovered molecules and has realized close to $700 million in cash from equity/BD activities, plus potential milestones up to $5 billion and royalties on 15 programs.
Clinical Progress in Wholly Owned Programs
SGR3515 (WE1 inhibitor) Phase 1: generally well tolerated on intermittent dosing with initial biomarker validation and 65% disease control rate among evaluable patients at doses ≥100 mg. SGR1505 (MORT1 inhibitor): 100% response rate with durable responses in Waldenström's macroglobulinemia; holds FDA Fast Track and Orphan Drug designations.
Expense Discipline and Strong Cash Position
Total operating expenses decreased 4% to $78 million (Q1 2026 vs Q1 2025). Ending cash and marketable securities reported at $406 million. Management expects operating expenses for FY2026 to be less than 2025 and anticipates only ~$10M–$15M of R&D spend to complete clinical activities as those wind down.