Strong Quarterly Net Product Sales Growth
Net product sales of $54.9M in Q1 2026, up 26% year-over-year (+$11.3M vs Q1 2025), driven by across‑portfolio strength and improving demand in March.
TAVALISSE Outperformance
TAVALISSE net product sales of $37.3M in Q1 2026, up 31% year-over-year, driven by stronger demand and a favorable gross-to-net comparison versus prior year.
REZLIDHIA Rapid Growth and Commercial Momentum
REZLIDHIA net product sales of $8.0M in Q1 2026, up 31% year-over-year, with growing breadth and depth in academic accounts and focused efforts to expand adoption in community settings.
GAVRETO Stable Contributor
GAVRETO net product sales of $9.6M in Q1 2026, up 7% year-over-year, representing a stable, recurring revenue contribution (~$10M quarterly level).
Total Revenue and Contract Revenues
Total revenue of $58.8M in Q1 2026, including $3.9M of contract/collaboration revenues from partners (Grifols, Kissei, Medison) expanding international availability.
Profitability and Financial Guidance Maintained
Company reiterated 2026 guidance: total revenue $275M–$290M, net product sales $255M–$265M, contract revenues $20M–$25M, and expects positive net income for full-year 2026.
R289 Clinical Progress with Promising Early Efficacy
R289 (dual IRAK1/4 inhibitor) Phase Ib dose-escalation data: in 18 evaluable patients at ≥500 mg, 6 (33%) achieved ≥8-week red cell transfusion independence (median duration ~23 weeks; median time to onset ~2 months); generally well tolerated with low incidence of grade 3/4 cytopenias/infections; Fast Track and Orphan Drug designations in place.
Operational and Balance Sheet Strength
Achieved profitability in Q3 2024 and maintained financial discipline; ended Q1 2026 with $146.7M cash, cash equivalents and short-term investments; restructured debt to a $40M revolving credit facility (option to $60M) for flexible financing.
Business Development Focus
Clear strategy to in-license or acquire late-stage hematology/oncology assets with potential near-term launches (next 3 years) to leverage existing infrastructure and accelerate revenue.