We are at ASGCT this week and caught ProQR's oral session on cholestatic diseases and their two posters on Rett and MASH. Cholestatic Diseases: ProQR presented preclinical data and Ph1 trial design for AX-0810, an RNA editing oligo for cholestatic diseases. Presentation was substantially similar to OTS Meeting, and supports 0810's potential to reduce liver bile accumulation in primary sclerosing cholangitis (PSC). AX-0810 introduces a de novo edit, so Ph1 healthy volunteer data should give us a good picture of in vivo editing capabilities.