Progress on TakeAim Lymphoma (PCNSL) Registrational Study
Continued steady progress on the single-arm registrational TakeAim Lymphoma study in relapsed/refractory primary CNS lymphoma (PCNSL) with an ORR endpoint; company expects the study to support accelerated submissions in the U.S. and Europe and anticipates updated combination data with ibrutinib in the first half of 2027. Enrollment is described as 'on track' despite the ultra-orphan patient population.
Initiation and Near-Term Milestones for CLL Proof‑of‑Concept Study
TakeAim CLL combination study (emavusertib + zanubrutinib) planning dosing of the initial 5 patients by mid‑2026 with initial data expected in December (2026); study will evaluate two doses (100 mg and 200 mg) to satisfy Project Optimus requirements and assess potential for deeper responses (CR/MRD‑negative) enabling time‑limited treatment.
Encouraging Early Clinical Data in Gastroesophageal Cancer
Collaborator presented initial poster data at ASCO GI showing results for 16 evaluable patients treated with emavusertib + FOLFOX + anti‑PD‑1 ± Herceptin in first‑line metastatic/unresectable gastroesophageal cancer, reporting a manageable toxicity profile and encouraging preliminary efficacy signals.
Collaborations and Regulatory Engagement
Ongoing collaborations with Aurigene, the NCI, academic KOLs (including Siteman/Washington University), and productive discussions with both FDA and EMA that informed trial design and accelerated pathway expectations.
Operating Expense and R&D Efficiency
Research & development expenses decreased to $6.4 million in Q1 2026 from $8.5 million in Q1 2025, a decline of $2.1 million or ~24.7%, primarily due to lower employee‑related and manufacturing costs.
Cash Position and Contingent Financing That Extends Runway
Cash and cash equivalents of $15.0 million as of March 31, 2026, plus anticipated gross proceeds of up to $20.2 million from exercise of January 2026 PIPE Series B warrants contingent on dosing the fifth CLL patient — company states this should enable planned operations into the second half of 2027.